SLC2A4 and ACOX1

Data Source:
HPRD (in vivo)

		SLC2A4	ACOX1
Description		solute carrier family 2 member 4	acyl-CoA oxidase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Multivesicular Body Trans-Golgi Network Cytosol Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Endomembrane System Vesicle Membrane Membrane Sarcoplasmic Reticulum Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle T-tubule Cytoplasmic Vesicle Membrane Insulin-responsive Compartment Sarcolemma Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Presynapse	Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Membrane
	Molecular Function	Glucose Transmembrane Transporter Activity Protein Binding D-glucose Transmembrane Transporter Activity	Acyl-CoA Oxidase Activity Fatty Acid Binding Palmitoyl-CoA Oxidase Activity PDZ Domain Binding Protein Homodimerization Activity Protein N-terminus Binding Flavin Adenine Dinucleotide Binding FAD Binding
	Biological Process	Carbohydrate Metabolic Process Learning Or Memory Short-term Memory Long-term Memory Amylopectin Biosynthetic Process Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Cellular Response To Insulin Stimulus Glucose Homeostasis Glucose Import In Response To Insulin Stimulus Response To Ethanol Glucose Import Brown Fat Cell Differentiation Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Osmotic Stress Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Transport Across Blood-brain Barrier Glucose Transmembrane Transport	Very Long-chain Fatty Acid Metabolic Process Generation Of Precursor Metabolites And Energy Protein Targeting To Peroxisome Lipid Metabolic Process Prostaglandin Metabolic Process Spermatogenesis Fatty Acid Catabolic Process Regulation Of Lipid Metabolic Process Fatty Acid Oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Hydrogen Peroxide Biosynthetic Process Lipid Homeostasis
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Cellular hexose transport Transcriptional regulation of white adipocyte differentiation	Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins
Drugs			Flavin adenine dinucleotide (3R)-3-HYDROXYDODECANOIC ACID
Diseases			Peroxisomal beta-oxidation enzyme deficiency, including: Acyl-CoA oxidase (ACOX) deficiency; D-bifunctional protein (DBP) deficiency; Perrault syndrome; Sterol carrier protein X (SCPx) deficiency; 2-Methylacyl-CoA racemase (AMCR) deficiency; Hypercholanemia
GWAS		Apolipoprotein B levels ( 32203549) Birth weight ( 23202124 31043758) Diastolic blood pressure ( 28135244) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Medication use (diuretics) ( 31015401) Metabolite levels ( 22286219) Offspring birth weight ( 31043758) Pulse pressure ( 28135244) Systolic blood pressure ( 30578418) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Body mass index ( 28552196) Diastolic blood pressure ( 27841878) Mean platelet volume ( 32888494) Pulse pressure ( 27841878) Systolic blood pressure ( 28135244 27841878) Urinary metabolite levels in chronic kidney disease ( 31959995) White matter hyperintensity burden ( 25663218)
Interacting Genes		40 interacting genes: ACOX1 ACTN1 ACTN4 AKT2 AP1M1 ARF3 ARFIP1 BSG C1QTNF5 CCDC116 CFL1 CREB3 CTSD DAXX DLD EHD2 ESYT2 FAR1 FKBP10 GAPDH HADH HK2 HSP90AA1 IDH2 KLHL41 LNPEP MAP1S MVP P3H1 P3H4 PDIA6 PRKAR1A PSMD7 RAB7A SERPINH1 SRFBP1 STRN3 UBA52 UBE2I UBE2N	3 interacting genes: SCP2 SLC2A4 TYSND1
Entrez ID		6517	51
HPRD ID		00688	02030
Ensembl ID		ENSG00000181856	ENSG00000161533
Uniprot IDs		P14672	Q15067
PDB IDs
Enriched GO Terms of Interacting Partners?
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