SLC2A4 and IDH2

Data Source:
HPRD (in vivo)

		SLC2A4	IDH2
Description		solute carrier family 2 member 4	isocitrate dehydrogenase (NADP(+)) 2
Image		No pdb structure
GO Annotations	Cellular Component	Multivesicular Body Trans-Golgi Network Cytosol Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Endomembrane System Vesicle Membrane Membrane Sarcoplasmic Reticulum Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle T-tubule Cytoplasmic Vesicle Membrane Insulin-responsive Compartment Sarcolemma Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Presynapse	Mitochondrion Mitochondrial Matrix Peroxisome Cytosol Extracellular Exosome
	Molecular Function	Glucose Transmembrane Transporter Activity Protein Binding D-glucose Transmembrane Transporter Activity	Magnesium Ion Binding Isocitrate Dehydrogenase (NADP+) Activity NAD Binding
	Biological Process	Carbohydrate Metabolic Process Learning Or Memory Short-term Memory Long-term Memory Amylopectin Biosynthetic Process Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Cellular Response To Insulin Stimulus Glucose Homeostasis Glucose Import In Response To Insulin Stimulus Response To Ethanol Glucose Import Brown Fat Cell Differentiation Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Osmotic Stress Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Transport Across Blood-brain Barrier Glucose Transmembrane Transport	Carbohydrate Metabolic Process Glyoxylate Cycle Tricarboxylic Acid Cycle Isocitrate Metabolic Process 2-oxoglutarate Metabolic Process NADP Metabolic Process NADP Biosynthetic Process Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Glial Cell Migration Negative Regulation Of Matrix Metallopeptidase Secretion
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Cellular hexose transport Transcriptional regulation of white adipocyte differentiation	Transcriptional activation of mitochondrial biogenesis Citric acid cycle (TCA cycle)
Drugs			Isocitric Acid Enasidenib
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Birth weight ( 23202124 31043758) Diastolic blood pressure ( 28135244) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Medication use (diuretics) ( 31015401) Metabolite levels ( 22286219) Offspring birth weight ( 31043758) Pulse pressure ( 28135244) Systolic blood pressure ( 30578418) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Cerebrospinal fluid clusterin levels ( 26545630) Pulse pressure ( 27841878 30578418) Urate levels ( 31578528)
Interacting Genes		40 interacting genes: ACOX1 ACTN1 ACTN4 AKT2 AP1M1 ARF3 ARFIP1 BSG C1QTNF5 CCDC116 CFL1 CREB3 CTSD DAXX DLD EHD2 ESYT2 FAR1 FKBP10 GAPDH HADH HK2 HSP90AA1 IDH2 KLHL41 LNPEP MAP1S MVP P3H1 P3H4 PDIA6 PRKAR1A PSMD7 RAB7A SERPINH1 SRFBP1 STRN3 UBA52 UBE2I UBE2N	3 interacting genes: FBXO7 PYGL SLC2A4
Entrez ID		6517	3418
HPRD ID		00688	00973
Ensembl ID		ENSG00000181856	ENSG00000182054
Uniprot IDs		P14672	B4DSZ6 P48735
PDB IDs			4JA8 5GIS 5I95 5I96 5SVN 5SVO 6ADI 6VFZ
Enriched GO Terms of Interacting Partners?
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