RBM15 and CD2

Data Source:
BioGRID (biochemical)

		RBM15	CD2
Description		RNA binding motif protein 15	CD2 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck Nuclear Membrane RNA N6-methyladenosine Methyltransferase Complex	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Protein-containing Complex Membrane Raft Anchored Component Of Plasma Membrane
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	Signaling Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Receptor Activity Identical Protein Binding Protein Self-association
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Methylation Branching Involved In Blood Vessel Morphogenesis Positive Regulation Of Transcription Of Notch Receptor Target Dosage Compensation By Inactivation Of X Chromosome Viral Process Thrombopoietin-mediated Signaling Pathway Negative Regulation Of Myeloid Cell Differentiation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Spleen Development Ventricular Septum Morphogenesis Placenta Blood Vessel Development	Membrane Raft Polarization Apoptotic Process Cell Surface Receptor Signaling Pathway Natural Killer Cell Activation Positive Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of T Cell Differentiation Leukocyte Migration Cell-cell Adhesion
Pathways			Cell surface interactions at the vascular wall
Drugs			Alefacept Siplizumab
Diseases
GWAS			Body mass index ( 28552196) Gout (normal type) ( 32238385) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)
Interacting Genes		12 interacting genes: ABI1 CALCOCO2 CEP44 CLK1 CNOT4 DDX17 LZTS2 MAPK8 NAV2 PRMT1 SRPK2 TSPYL2	21 interacting genes: CD247 CD2AP CD2BP2 CD4 CD48 CD5 CD53 CD58 CD59 DNAJC5 FYN LCK LGALS1 LINC00311 LYAR MXD1 PSTPIP1 PTPRC SH3KBP1 SP1 UBC
Entrez ID		64783	914
HPRD ID		05832	01750
Ensembl ID		ENSG00000162775	ENSG00000116824
Uniprot IDs		Q96T37	P06729 Q53F96
PDB IDs			1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I
Enriched GO Terms of Interacting Partners?
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