POLR1E and SIRT7

Data Source:
BioGRID (pull down, affinity chromatography technology)

		POLR1E	SIRT7
Description		RNA polymerase I subunit E	sirtuin 7
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Nucleolus RNA Polymerase I Complex	Chromatin Nucleus Nucleoplasm Nucleolus Nucleolus Organizer Region Cytoplasm Nuclear Speck Site Of Double-strand Break
	Molecular Function	RNA Polymerase I General Transcription Initiation Factor Binding DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding	Chromatin Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Deacetylase Activity NAD-dependent Protein Deacetylase Activity Protein-succinyllysine Desuccinylase Activity Metal Ion Binding Protein-glutaryllysine Deglutarylase Activity NAD+ Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific) Protein-propionyllysine Depropionylase Activity
	Biological Process	RNA Polymerase I Preinitiation Complex Assembly Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Nucleolar Large RRNA Transcription By RNA Polymerase I Positive Regulation Of Gene Expression, Epigenetic	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of Gluconeogenesis DNA Repair Regulation Of DNA Repair Protein Deacetylation Cellular Response To DNA Damage Stimulus Positive Regulation Of Transcription Involved In Exit From Mitosis Homologous Chromosome Pairing At Meiosis RRNA Transcription Negative Regulation Of Transposition Regulation Of Mitochondrion Organization Histone Modification Negative Regulation Of Protein Ubiquitination Peptidyl-lysine Desuccinylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Export From Nucleus Protein Deglutarylation Peptidyl-lysine Deglutarylation R-loop Disassembly Histone H3 Deacetylation Histone H4 Deacetylation Protein Depropionylation Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Histone Glutamine Methylation Positive Regulation Of RRNA Processing Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS
Interacting Genes		8 interacting genes: NFKBIB POLR1A POLR1B POLR1C POLR1G SIRT7 TAF1C UBTF	12 interacting genes: APP DDB1 FBL H2AC20 H2BC21 H3C1 H4C1 MAGED1 POLR1E RRP9 USP7 WDR77
Entrez ID		64425	51547
HPRD ID		15096	12094
Ensembl ID		ENSG00000137054	ENSG00000187531
Uniprot IDs		B4E005 Q9GZS1	Q9NRC8
PDB IDs			5IQZ 6G0S
Enriched GO Terms of Interacting Partners?
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