SEMG1 and TGM1

Data Source:
HPRD (in vitro)

		SEMG1	TGM1
Description		semenogelin 1	transglutaminase 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Protein-containing Complex Extracellular Exosome	Cornified Envelope Cytosol Plasma Membrane Membrane Intrinsic Component Of Membrane Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Insemination Antimicrobial Humoral Response Antibacterial Humoral Response Killing Of Cells Of Other Organism Cellular Protein Metabolic Process Sperm Capacitation Coagulation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Negative Regulation Of Calcium Ion Import Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Flagellated Sperm Motility	Cellular Protein Modification Process Positive Regulation Of Keratinocyte Proliferation Peptide Cross-linking Protein Phosphopantetheinylation Keratinocyte Differentiation Cell Envelope Organization Positive Regulation Of Cell Cycle Cornification
Pathways		Antimicrobial peptides Amyloid fiber formation	Formation of the cornified envelope
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 28240269) Malaria ( 31844061)
Interacting Genes		9 interacting genes: EAF1 KLK2 KLK3 PRKCA PTPRF SEMG2 TGM1 UBQLN2 UBQLN4	34 interacting genes: ACADL ALPP C1QTNF1 CNNM3 CRCT1 CXCL16 DOCK2 GSTP1 HSPB1 IFI30 IGSF8 ITGB4 JOSD1 KRTAP4-12 KRTAP5-9 LCE1B LCE1E LCE3A LCE4A MDK MYPOP NECTIN2 NUBP2 PLAAT4 RIN3 SCARF1 SEMG1 SEMG2 SNCA SULT4A1 TACC2 TRAPPC14 VASN VSTM4
Entrez ID		6406	7051
HPRD ID		01641	01824
Ensembl ID		ENSG00000124233	ENSG00000092295
Uniprot IDs		P04279	P22735
PDB IDs			2XZZ
Enriched GO Terms of Interacting Partners?
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