CXCL5 and CCL11

Data Source:
BioGRID (pull down)

		CXCL5	CCL11
Description		C-X-C motif chemokine ligand 5	C-C motif chemokine ligand 11
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Chemokine Activity Identical Protein Binding CXCR Chemokine Receptor Binding	Protein Binding Chemokine Activity CCR3 Chemokine Receptor Binding Protein Dimerization Activity Receptor Ligand Activity CCR Chemokine Receptor Binding
	Biological Process	Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Neutrophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide	Positive Regulation Of Endothelial Cell Proliferation Chronic Inflammatory Response Monocyte Chemotaxis Mast Cell Chemotaxis Protein Phosphorylation Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Cytoskeleton Organization Actin Filament Organization Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Learning Or Memory Regulation Of Cell Shape Response To Radiation Response To Virus Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of Actin Filament Polymerization Response To Interleukin-13 Positive Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Eosinophil Chemotaxis Lymphocyte Chemotaxis Negative Regulation Of Neurogenesis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Duct Terminal End Bud Growth Chemokine-mediated Signaling Pathway ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-4 Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Modulation Of Age-related Behavioral Decline
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Chemokine receptors bind chemokines Interleukin-4 and Interleukin-13 signaling
Drugs			CAT-213
Diseases
GWAS		CXCL5 levels ( 25147954) Inflammatory bowel disease ( 23128233) Metabolite levels ( 22916037) Urate levels (BMI interaction) ( 25811787)	Crohn's disease ( 28067908 22412388) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908 23128233)
Interacting Genes		20 interacting genes: ACKR1 ACTN3 ALPP CCL11 CCL20 CXCL1 CXCL14 CXCL2 CXCL3 CXCR1 CXCR2 EFEMP2 FBLN1 GRN MEOX2 MGAT5B MMP9 NOTCH2NLA VWC2L XCL2	29 interacting genes: ACKR2 ACKR4 CCL13 CCL14 CCL18 CCL2 CCL26 CCL27 CCL28 CCL5 CCL8 CCR3 CCR5 CXCL1 CXCL10 CXCL11 CXCL12 CXCL14 CXCL2 CXCL3 CXCL5 CXCL6 CXCL9 DPP4 NUDT3 PF4 PF4V1 TPI1 XCL1
Entrez ID		6374	6356
HPRD ID		08976	03098
Ensembl ID		ENSG00000163735	ENSG00000172156
Uniprot IDs		P42830 Q6I9S7	P51671 Q6I9T4
PDB IDs		2MGS	1EOT 2EOT 2MPM
Enriched GO Terms of Interacting Partners?
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