CCL11 and CCL14

Data Source:
BioGRID (pull down)

		CCL11	CCL14
Description		C-C motif chemokine ligand 11	C-C motif chemokine ligand 14
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Space
	Molecular Function	Protein Binding Chemokine Activity CCR3 Chemokine Receptor Binding Protein Dimerization Activity Receptor Ligand Activity CCR Chemokine Receptor Binding	Chemokine Activity CCR Chemokine Receptor Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Chronic Inflammatory Response Monocyte Chemotaxis Mast Cell Chemotaxis Protein Phosphorylation Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Cytoskeleton Organization Actin Filament Organization Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Learning Or Memory Regulation Of Cell Shape Response To Radiation Response To Virus Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of Actin Filament Polymerization Response To Interleukin-13 Positive Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Eosinophil Chemotaxis Lymphocyte Chemotaxis Negative Regulation Of Neurogenesis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Duct Terminal End Bud Growth Chemokine-mediated Signaling Pathway ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-4 Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Modulation Of Age-related Behavioral Decline	Monocyte Chemotaxis Cellular Calcium Ion Homeostasis Inflammatory Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Lymphocyte Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor
Pathways		Chemokine receptors bind chemokines Interleukin-4 and Interleukin-13 signaling
Drugs		CAT-213
Diseases
GWAS		Crohn's disease ( 28067908 22412388) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908 23128233)	Blood protein levels ( 30072576 29875488 28240269) Metabolite levels ( 23823483) Upper eyelid sagging severity ( 24869959)
Interacting Genes		29 interacting genes: ACKR2 ACKR4 CCL13 CCL14 CCL18 CCL2 CCL26 CCL27 CCL28 CCL5 CCL8 CCR3 CCR5 CXCL1 CXCL10 CXCL11 CXCL12 CXCL14 CXCL2 CXCL3 CXCL5 CXCL6 CXCL9 DPP4 NUDT3 PF4 PF4V1 TPI1 XCL1	9 interacting genes: ACKR2 AKT2 CCL11 CCL22 CCR1 CCR3 CCR5 DDX39A PIK3R1
Entrez ID		6356	6358
HPRD ID		03098	03231
Ensembl ID		ENSG00000172156	ENSG00000276409
Uniprot IDs		P51671 Q6I9T4	Q16627
PDB IDs		1EOT 2EOT 2MPM	2Q8R 2Q8T
Enriched GO Terms of Interacting Partners?
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