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MAPK12 and EEF2K
Data Source:
HPRD
(in vitro)
MAPK12
EEF2K
Description
mitogen-activated protein kinase 12
eukaryotic elongation factor 2 kinase
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Cytoplasm
Cytosol
Postsynaptic Density
Dendritic Spine
Molecular Function
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Activity
Elongation Factor-2 Kinase Activity
Calcium Ion Binding
Calmodulin Binding
ATP Binding
Translation Factor Activity, RNA Binding
Biological Process
MAPK Cascade
DNA Damage Induced Protein Phosphorylation
Cell Cycle Arrest
Signal Transduction
Muscle Organ Development
Positive Regulation Of Peptidase Activity
Peptidyl-serine Phosphorylation
Intracellular Signal Transduction
Myoblast Differentiation
Positive Regulation Of Muscle Cell Differentiation
Response To Ischemia
Translational Elongation
Regulation Of Protein Autophosphorylation
Cellular Response To Insulin Stimulus
Negative Regulation Of Apoptotic Process
Positive Regulation Of Endocytosis
Protein Autophosphorylation
Positive Regulation Of Synapse Assembly
Positive Regulation Of Dendritic Spine Morphogenesis
Cellular Response To Calcium Ion
Cellular Response To CAMP
Cellular Response To Anoxia
Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Response To Prolactin
Pathways
NOD1/2 Signaling Pathway
p38MAPK events
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
DSCAM interactions
VEGFA-VEGFR2 Pathway
Myogenesis
Myogenesis
Negative regulation of MAPK pathway
mTORC1-mediated signalling
Drugs
Minocycline
Phosphonothreonine
Phosphoaminophosphonic Acid-Adenylate Ester
KC706
CEP-1347
Diseases
GWAS
Acne (severe) (
24927181
)
Diverticular disease (
30177863
)
Triiodothyronine levels and thyroxine levels (
30843173
)
Heel bone mineral density (
30598549
)
Interacting Genes
29 interacting genes:
DLG1
DLG2
DLG3
DLG4
DUSP1
EEF2K
ERBIN
GRB2
GTF2I
HTRA2
MAP2K3
MAP2K4
MAP2K6
MAPKAPK5
MAPT
MBP
PATJ
PDGFRL
PKN1
PTPN3
PTPN4
RCSD1
RGS3
SH3BP5
SIAH1
SNTA1
SNTB1
SRPK1
TERF1
17 interacting genes:
CDK1
EEF2
MAPK11
MAPK12
MAPK13
MAPK14
MAPK8
MAPK9
MAPKAPK2
MAPKAPK3
MAPKAPK5
PRKAA1
PRKAA2
PRKACA
RPS6KA1
RPS6KB1
RPS6KB2
Entrez ID
6300
29904
HPRD ID
03868
07369
Ensembl ID
ENSG00000188130
ENSG00000103319
Uniprot IDs
P53778
Q6N076
O00418
PDB IDs
1CM8
4QUM
6UNA
5J8H
5KS5
6NX4
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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