RFC4 and CHTF18

Data Source:
HPRD (in vivo)

		RFC4	CHTF18
Description		replication factor C subunit 4	chromosome transmission fidelity factor 18
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Ctf18 RFC-like Complex Elg1 RFC-like Complex	Nucleus Nucleoplasm Cytosol Membrane Ctf18 RFC-like Complex
	Molecular Function	DNA Clamp Loader Activity Protein Binding ATP Binding Single-stranded DNA Helicase Activity	DNA Binding DNA Clamp Loader Activity Protein Binding ATP Binding Single-stranded DNA Helicase Activity
	Biological Process	DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication DNA Duplex Unwinding Nucleotide-excision Repair, DNA Incision Error-prone Translesion Synthesis DNA Damage Response, Detection Of DNA Damage Error-free Translesion Synthesis Positive Regulation Of DNA-directed DNA Polymerase Activity Regulation Of Signal Transduction By P53 Class Mediator	DNA Replication Cell Cycle DNA Duplex Unwinding Positive Regulation Of DNA-directed DNA Polymerase Activity
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint	Polymerase switching on the C-strand of the telomere
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881)	Body mass index ( 26426971) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		13 interacting genes: BRD4 CDK4 CHTF18 HDAC1 PCNA PTEN RAD17 RFC2 RFC3 RFC5 RNF41 SUMO2 TRIM28	5 interacting genes: CRK PCNA RFC4 RFC5 STAT3
Entrez ID		5984	63922
HPRD ID		00022	13059
Ensembl ID		ENSG00000163918	ENSG00000127586
Uniprot IDs		P35249	Q8WVB6
PDB IDs		6VVO
Enriched GO Terms of Interacting Partners?
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