RAD23A and RPN1

Data Source:
HPRD (in vivo, in vitro)

		RAD23A	RPN1
Description		RAD23 homolog A, nucleotide excision repair protein	ribophorin I
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GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Centriolar Satellite Intracellular Membrane-bounded Organelle	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Cytosol Oligosaccharyltransferase Complex Membrane Integral Component Of Membrane Melanosome
	Molecular Function	Damaged DNA Binding Single-stranded DNA Binding Protein Binding Kinase Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Proteasome Binding Ubiquitin-specific Protease Binding	RNA Binding Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding
	Biological Process	Nucleotide-excision Repair Viral Process Protein Deubiquitination Protein Destabilization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Genome Replication Positive Regulation Of Cell Cycle	Cellular Protein Modification Process Protein N-linked Glycosylation Protein N-linked Glycosylation Via Asparagine
Pathways		Josephin domain DUBs DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER	SRP-dependent cotranslational protein targeting to membrane Asparagine N-linked glycosylation Maturation of spike protein
Drugs
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353)	Blood protein levels ( 30072576 29875488) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Eosinophil counts ( 29403010 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mild to moderate chronic kidney disease ( 31178898) Monocyte count ( 23314186 29403010 27863252) Monocyte percentage of white cells ( 32888494 27863252) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Neutrophil count ( 32888494) Platelet distribution width ( 32888494) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494 21738480) White blood cell count (basophil) ( 29403010)
Interacting Genes		76 interacting genes: A2M ADRM1 ANKRD40 ATXN3 ATXN7 CCNA2 CDC37 CHEK1 CNTROB CREBBP DAZAP2 DBI ECSIT EP300 EWSR1 FILIP1 GTF2H1 HSPB1 IFIT3 IFIT5 KRTAP12-2 LOXL4 MAP3K1 MAST1 MDM2 MINDY3 MKRN1 MPG NEDD8 NGLY1 NUTM2F PDE6D PHAX PI4K2A PRKN PSEN1 PSMC5 PSMD4 RABGEF1 REL RNF115 RNF32 RNF41 RPN1 RPS27A SH3RF1 SMURF1 SQSTM1 TNFAIP3 TRAF2 TRAF3 TRAF5 TRAF6 TRIM39 TRIM50 TRIM54 TRIM55 TRIM8 TRIP6 UBA52 UBB UBC UBE3A UBE4B UBL7 UBQLN2 UBQLN4 UBXN1 UIMC1 USP25 VAV2 XPC ZBTB26 ZBTB44 ZBTB8A ZFAND6	17 interacting genes: ADRM1 CAMLG DPF1 DUX4 ERBB3 HSPA5 KRTAP1-3 RAD23A RBBP4 SGTA SIGIRR SMARCB1 UBC UBQLN1 UBQLN2 UBQLN4 WSB2
Entrez ID		5886	6184
HPRD ID		07191	01598
Ensembl ID		ENSG00000179262	ENSG00000163902
Uniprot IDs		A0A024R7G8 A8K1J3 P54725	P04843
PDB IDs		1DV0 1F4I 1IFY 1OQY 1P98 1P9D 1QZE 1TP4 1ZO6 2WYQ 5XBO	6S7O 6S7T
Enriched GO Terms of Interacting Partners?
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