Wiki-Pi
About
Search
Browse
People
Updates
Search
PTPN2 and JAK1
Data Source:
HPRD
(in vitro, in vivo)
PTPN2
JAK1
Description
protein tyrosine phosphatase non-receptor type 2
Janus kinase 1
Image
GO Annotations
Cellular Component
Nucleoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum-Golgi Intermediate Compartment
Cytosol
Plasma Membrane
Nucleus
Cytoplasm
Endosome
Cytosol
Cytoskeleton
Focal Adhesion
Membrane
Molecular Function
Protein Tyrosine Phosphatase Activity
Non-membrane Spanning Protein Tyrosine Phosphatase Activity
Integrin Binding
Protein Binding
Protein Kinase Binding
Syntaxin Binding
Receptor Tyrosine Kinase Binding
STAT Family Protein Binding
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Growth Hormone Receptor Binding
Protein Binding
ATP Binding
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
CCR5 Chemokine Receptor Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Lipid Storage
B Cell Differentiation
T Cell Differentiation
Erythrocyte Differentiation
Peptidyl-tyrosine Dephosphorylation
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein
Glucose Homeostasis
Negative Regulation Of Macrophage Differentiation
Positive Regulation Of Gluconeogenesis
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response
Negative Regulation Of T Cell Receptor Signaling Pathway
Negative Regulation Of Chemotaxis
Regulation Of Interferon-gamma-mediated Signaling Pathway
Negative Regulation Of Interferon-gamma-mediated Signaling Pathway
Negative Regulation Of Type I Interferon-mediated Signaling Pathway
Negative Regulation Of Protein Tyrosine Kinase Activity
Negative Regulation Of Interleukin-6-mediated Signaling Pathway
Negative Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Cytokine Stimulus
Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway
Negative Regulation Of Interleukin-2-mediated Signaling Pathway
Negative Regulation Of Interleukin-4-mediated Signaling Pathway
Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway
Negative Regulation Of Positive Thymic T Cell Selection
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of PERK-mediated Unfolded Protein Response
Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
MAPK Cascade
Protein Phosphorylation
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Positive Regulation Of Homotypic Cell-cell Adhesion
Intracellular Signal Transduction
Interleukin-12-mediated Signaling Pathway
Interleukin-15-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Interleukin-21-mediated Signaling Pathway
Response To Antibiotic
Interferon-gamma-mediated Signaling Pathway
Regulation Of Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Interleukin-6-mediated Signaling Pathway
Interleukin-27-mediated Signaling Pathway
Interleukin-35-mediated Signaling Pathway
Protein Localization To Cell-cell Junction
Positive Regulation Of Sprouting Angiogenesis
Pathways
Negative regulation of MET activity
Interleukin-37 signaling
Interleukin-6 signaling
Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
ISG15 antiviral mechanism
Interleukin-7 signaling
Interleukin-7 signaling
Other interleukin signaling
RAF/MAP kinase cascade
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
IL-6-type cytokine receptor ligand interactions
Interferon gamma signaling
Regulation of IFNG signaling
Regulation of IFNG signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-15 signaling
Interleukin-35 Signalling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-12 signaling
Interleukin-12 signaling
Interleukin-27 signaling
Interleukin-27 signaling
Interleukin-21 signaling
Interferon alpha/beta signaling
Interleukin receptor SHC signaling
Regulation of IFNA signaling
Regulation of IFNA signaling
Potential therapeutics for SARS
Drugs
Myricetin
2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one
Ruxolitinib
Tofacitinib
Baricitinib
Fostamatinib
Fedratinib
Filgotinib
Upadacitinib
Pralsetinib
Diseases
Type I diabetes mellitus
GWAS
Alopecia areata (
25608926
)
Autoimmune thyroid disease (
32581359
)
Autoimmune traits (pleiotropy) (
30572963
)
Body mass index (
25673413
)
C-reactive protein levels (
30388399
21300955
)
Celiac disease (
22057235
20190752
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Celiac disease or Rheumatoid arthritis (
21383967
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
18587394
25489960
28067908
17554261
17554300
21102463
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Esophageal cancer (squamous cell) (
22960999
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Hemoglobin levels (
32327693
)
Inflammatory bowel disease (
28067908
)
Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) (
23603761
)
Lead levels in blood (
25820613
)
Lymphocyte counts (
32888494
)
Mean reticulocyte volume (
32888494
)
Medication use (thyroid preparations) (
31015401
)
Monocyte count (
32888494
)
Psoriasis (
28537254
)
Red blood cell count (
32888494
)
Rheumatoid arthritis (
30423114
22446963
23143596
24390342
)
Rheumatoid arthritis (ACPA-positive) (
24532676
)
Selective IgA deficiency (
27723758
)
Type 1 diabetes (
21829393
25751624
19430480
17554260
18978792
)
Autoimmune thyroid disease (
32581359
)
Core binding factor acute myeloid leukemia (
27903959
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Medication use (thyroid preparations) (
31015401
)
Monocyte percentage of white cells (
32888494
)
Multiple sclerosis (
31604244
)
Neutrophil percentage of granulocytes (
27863252
)
Plasma anti-thyroglobulin levels (
29678681
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Interacting Genes
23 interacting genes:
CDK1
CDK2
CDK5
EGFR
FAM220A
FKBP4
GHR
GJB1
INSR
ITGA1
JAK1
JAK3
KPNB1
OCLN
PDGFRB
SHC1
SRC
STAT1
STAT3
STAT5A
STAT5B
STX17
UBC
72 interacting genes:
ABL1
AGTR1
BRCA1
BTK
CCR1
CCR5
CSF2RB
CSF3R
CXCR4
EIF2AK2
ELP2
ERBB2
FER
FES
GAB1
GHR
GRB2
H3-4
IFNAR2
IFNGR1
IGF1R
IL10RA
IL21R
IL2RB
IL2RG
IL3RA
IL4R
IL5RA
IL6ST
IL7R
IL9R
INPP5D
INSR
IRS1
IRS2
JAK3
JAKMIP1
MDK
OSMR
PDGFRA
PDGFRB
PIK3R1
PLA2G4A
PLAUR
PLCG2
PRKCZ
PRMT5
PTK2B
PTPN11
PTPN2
PTPN6
PTPRC
RACK1
RAF1
SH2B2
SHB
SOCS1
SOCS3
STAM
STAM2
STAT1
STAT2
STAT3
STAT5A
STAT6
SYK
TEC
TNFRSF1A
TOP1
TSHR
TYK2
USP6
Entrez ID
5771
3716
HPRD ID
06768
00992
Ensembl ID
ENSG00000175354
ENSG00000162434
Uniprot IDs
A8K3N4
D3DUJ3
K7EQG9
P17706
Q59F91
P23458
Q6P669
PDB IDs
1L8K
3EYG
3EYH
4E4L
4E4N
4E5W
4EHZ
4EI4
4FK6
4GS0
4I5C
4IVB
4IVC
4IVD
4K6Z
4K77
4L00
4L01
5E1E
5HX8
5IXD
5IXI
5KHW
5KHX
5L04
5WO4
6AAH
6BBU
6C7Y
6DBN
6ELR
6GGH
6HZU
6N77
6N78
6N79
6N7A
6N7B
6N7C
6N7D
6RSB
6RSC
6RSD
6RSE
6RSH
6SM8
6SMB
6TPE
6TPF
6W8L
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?