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JAK1 and AGTR1
Data Source:
BioGRID
(two hybrid)
JAK1
AGTR1
Description
Janus kinase 1
angiotensin II receptor type 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Endosome
Cytosol
Cytoskeleton
Focal Adhesion
Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
Integral Component Of Membrane
Molecular Function
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Growth Hormone Receptor Binding
Protein Binding
ATP Binding
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
CCR5 Chemokine Receptor Binding
Metal Ion Binding
Angiotensin Type I Receptor Activity
G Protein-coupled Receptor Activity
Angiotensin Type II Receptor Activity
Protein Binding
Bradykinin Receptor Binding
Protein Heterodimerization Activity
Biological Process
MAPK Cascade
Protein Phosphorylation
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Positive Regulation Of Homotypic Cell-cell Adhesion
Intracellular Signal Transduction
Interleukin-12-mediated Signaling Pathway
Interleukin-15-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Interleukin-21-mediated Signaling Pathway
Response To Antibiotic
Interferon-gamma-mediated Signaling Pathway
Regulation Of Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Interleukin-6-mediated Signaling Pathway
Interleukin-27-mediated Signaling Pathway
Interleukin-35-mediated Signaling Pathway
Protein Localization To Cell-cell Junction
Positive Regulation Of Sprouting Angiogenesis
Regulation Of Cell Growth
Kidney Development
Renin-angiotensin Regulation Of Aldosterone Production
Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin
Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin
Inflammatory Response
G Protein-coupled Receptor Signaling Pathway
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Rho Protein Signal Transduction
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Cholesterol Esterification
Regulation Of Vasoconstriction
Calcium-mediated Signaling
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Phospholipase A2 Activity
Positive Regulation Of NAD(P)H Oxidase Activity
Low-density Lipoprotein Particle Remodeling
Regulation Of Renal Sodium Excretion
Angiotensin-activated Signaling Pathway
Regulation Of Cell Population Proliferation
Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway
Cell Chemotaxis
Phospholipase C-activating Angiotensin-activated Signaling Pathway
Blood Vessel Diameter Maintenance
Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Interleukin-6 signaling
Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
ISG15 antiviral mechanism
Interleukin-7 signaling
Interleukin-7 signaling
Other interleukin signaling
RAF/MAP kinase cascade
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
IL-6-type cytokine receptor ligand interactions
Interferon gamma signaling
Regulation of IFNG signaling
Regulation of IFNG signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-15 signaling
Interleukin-35 Signalling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-12 signaling
Interleukin-12 signaling
Interleukin-27 signaling
Interleukin-27 signaling
Interleukin-21 signaling
Interferon alpha/beta signaling
Interleukin receptor SHC signaling
Regulation of IFNA signaling
Regulation of IFNA signaling
Potential therapeutics for SARS
Peptide ligand-binding receptors
G alpha (q) signalling events
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Drugs
Myricetin
2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one
Ruxolitinib
Tofacitinib
Baricitinib
Fostamatinib
Fedratinib
Filgotinib
Upadacitinib
Pralsetinib
Valsartan
Olmesartan
Losartan
Candesartan cilexetil
Eprosartan
Telmisartan
Irbesartan
Forasartan
Saprisartan
Tasosartan
CYT006-AngQb
Azilsartan medoxomil
Fimasartan
Angiotensin II
Candesartan
Diseases
Renal tubular dysgenesis
GWAS
Autoimmune thyroid disease (
32581359
)
Core binding factor acute myeloid leukemia (
27903959
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Medication use (thyroid preparations) (
31015401
)
Monocyte percentage of white cells (
32888494
)
Multiple sclerosis (
31604244
)
Neutrophil percentage of granulocytes (
27863252
)
Plasma anti-thyroglobulin levels (
29678681
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Birth weight (
31043758
)
Chin dimples (
27182965
)
Height (
31562340
)
Lead levels in blood (
25820613
)
Monobrow (
27182965
)
Type 2 diabetes (
31049640
)
Interacting Genes
72 interacting genes:
ABL1
AGTR1
BRCA1
BTK
CCR1
CCR5
CSF2RB
CSF3R
CXCR4
EIF2AK2
ELP2
ERBB2
FER
FES
GAB1
GHR
GRB2
H3-4
IFNAR2
IFNGR1
IGF1R
IL10RA
IL21R
IL2RB
IL2RG
IL3RA
IL4R
IL5RA
IL6ST
IL7R
IL9R
INPP5D
INSR
IRS1
IRS2
JAK3
JAKMIP1
MDK
OSMR
PDGFRA
PDGFRB
PIK3R1
PLA2G4A
PLAUR
PLCG2
PRKCZ
PRMT5
PTK2B
PTPN11
PTPN2
PTPN6
PTPRC
RACK1
RAF1
SH2B2
SHB
SOCS1
SOCS3
STAM
STAM2
STAT1
STAT2
STAT3
STAT5A
STAT6
SYK
TEC
TNFRSF1A
TOP1
TSHR
TYK2
USP6
76 interacting genes:
ABI3
ADD3
AGT
AGTRAP
AP2M1
ARFGAP1
ARHGDIG
ARRB1
ARRB2
ATP13A1
ATP1B1
BAALC
BASP1
BDKRB2
BNIP3
BRD8
CBR1
CCDC25
CD37
CERS6
CUEDC2
DBNDD2
DNAJC14
DNAJC8
EGFR
FAM13B
FBXW11
FNBP1
GHITM
GNA12
GOT1
GPAA1
GPRASP1
GRK2
GRK3
GRK5
HDGFL2
HHATL
HRAS
JAK1
JAK2
JKAMP
KIAA0930
LCNL1
LLGL1
LZTS1
NACAD
NDRG2
NOS3
NPTN
NUP88
OAZ1
PCMT1
PDE6H
PLCG1
PLCH2
PNMA1
PPP1R3F
PSMD10
PTGFR
RAB5A
RAF1
RBSN
RTN3
SAE1
SCG5
SELENOF
SERINC3
SLC16A1
SPG21
THOP1
TMEM161A
TMEM80
UBR4
UGT8
YWHAQ
Entrez ID
3716
185
HPRD ID
00992
00107
Ensembl ID
ENSG00000162434
ENSG00000144891
Uniprot IDs
P23458
Q6P669
A0A0A0MSE3
D3DNG8
P30556
Q53YY0
Q6NUP5
PDB IDs
3EYG
3EYH
4E4L
4E4N
4E5W
4EHZ
4EI4
4FK6
4GS0
4I5C
4IVB
4IVC
4IVD
4K6Z
4K77
4L00
4L01
5E1E
5HX8
5IXD
5IXI
5KHW
5KHX
5L04
5WO4
6AAH
6BBU
6C7Y
6DBN
6ELR
6GGH
6HZU
6N77
6N78
6N79
6N7A
6N7B
6N7C
6N7D
6RSB
6RSC
6RSD
6RSE
6RSH
6SM8
6SMB
6TPE
6TPF
6W8L
1ZV0
4YAY
4ZUD
6DO1
6OS0
6OS1
6OS2
Enriched GO Terms of Interacting Partners
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