KLHL1 and BMPR1B

Data Source:
HPRD (in vivo)

		KLHL1	BMPR1B
Description		kelch like family member 1	bone morphogenetic protein receptor type 1B
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Dendrite Neuronal Cell Body	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Neuronal Cell Body Receptor Complex HFE-transferrin Receptor Complex
	Molecular Function	Actin Binding Protein Binding	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding SMAD Binding Metal Ion Binding
	Biological Process	Adult Walking Behavior Dendrite Development Cerebellar Purkinje Cell Layer Development Actin Cytoskeleton Organization	Skeletal System Development Cartilage Condensation Ovarian Cumulus Expansion Eye Development Chondrocyte Development Protein Phosphorylation Inflammatory Response Dorsal/ventral Pattern Formation Proteoglycan Biosynthetic Process Positive Regulation Of Bone Mineralization BMP Signaling Pathway Retinal Ganglion Cell Axon Guidance Positive Regulation Of Chondrocyte Differentiation Limb Morphogenesis Ovulation Cycle Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Retina Development In Camera-type Eye Endochondral Bone Morphogenesis Positive Regulation Of Cartilage Development Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Chondrocyte Proliferation
Pathways			Signaling by BMP
Drugs			Fostamatinib
Diseases			Acromesomelic dysplasia with genital anomalies Brachydactyly, including: type A; type B; type D; type E
GWAS		Asthma (time to childhood onset) in early life tobacco smoke exposure ( 31379025) Asthma (time to childhood onset) x early life tobacco smoke interaction ( 31379025) Bilirubin levels ( 22085899) Chronotype ( 30696823) Cleft lip with or without cleft palate x maternal periconceptional vitamin use interaction (parent of origin effect) ( 31372216) Cognitive performance ( 19734545) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Mortality in sepsis ( 27639821) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) Response to amphetamines ( 22952603) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Tonsillectomy ( 27182965 28928442) Verbal declarative memory ( 25648963)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Attention deficit hyperactivity disorder ( 20732626) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778 33020668) Diverticular disease ( 30177863) Heel bone mineral density ( 30598549) Hen's egg allergy ( 29051540) Maximum stenosis ( 32469969) Polycystic ovary syndrome (reproductive subtype) ( 32574161) Prepulse inhibition of the startle response ( 31596458) Schizophrenia ( 30470734) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Systolic blood pressure ( 30224653 30578418) Waist-hip ratio ( 28552196)
Interacting Genes		2 interacting genes: BMPR1B TGFBR1	64 interacting genes: AMHR2 APP ARHGEF6 BAMBI BMP15 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR2 CDK14 CDK4 CHN1 DCAF12 DCAF6 DCAF7 FANCL GDF5 GDF6 GDF9 KLHL1 LZTR1 NKIRAS1 OTUB1 OXSR1 PAK1 PLEKHB1 POMK PPP2CA PPP3CC RAB25 RAB38 RAB6B RAN RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 SASH3 SH3KBP1 SMAD6 SMAD7 SNX6 SOCS6 SQSTM1 SRGAP1 STAMBP STK35 STUB1 TGFBR1 TNNT1 TRAF6 TTC17 TTC27 UBA52 UBE2Z UBXN1 USP45 VEPH1
Entrez ID		57626	658
HPRD ID		05623	04457
Ensembl ID		ENSG00000150361	ENSG00000138696
Uniprot IDs		B7Z3I8 F5H1J3 Q8TBJ7 Q9NR64	A8KAE3 O00238
PDB IDs			3MDY
Enriched GO Terms of Interacting Partners?
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