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BMPR1B and SASH3
Data Source:
HPRD
(in vivo)
BMPR1B
SASH3
Description
bone morphogenetic protein receptor type 1B
SAM and SH3 domain containing 3
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Dendrite
Neuronal Cell Body
Receptor Complex
HFE-transferrin Receptor Complex
Nucleus
Cytoplasm
Molecular Function
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta Receptor Activity, Type I
Protein Binding
ATP Binding
SMAD Binding
Metal Ion Binding
Biological Process
Skeletal System Development
Cartilage Condensation
Ovarian Cumulus Expansion
Eye Development
Chondrocyte Development
Protein Phosphorylation
Inflammatory Response
Dorsal/ventral Pattern Formation
Proteoglycan Biosynthetic Process
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Retinal Ganglion Cell Axon Guidance
Positive Regulation Of Chondrocyte Differentiation
Limb Morphogenesis
Ovulation Cycle
Positive Regulation Of Cell Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Retina Development In Camera-type Eye
Endochondral Bone Morphogenesis
Positive Regulation Of Cartilage Development
Cellular Response To Growth Factor Stimulus
Cellular Response To BMP Stimulus
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Chondrocyte Proliferation
Positive Regulation Of Immunoglobulin Production
Positive Regulation Of T Cell Cytokine Production
Positive Regulation Of Adaptive Immune Response
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of T Cell Proliferation
Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Positive Regulation Of Organ Growth
Homeostasis Of Number Of Cells Within A Tissue
Pathways
Signaling by BMP
Drugs
Fostamatinib
Diseases
Acromesomelic dysplasia with genital anomalies
Brachydactyly, including: type A; type B; type D; type E
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Attention deficit hyperactivity disorder (
20732626
)
Colorectal cancer or advanced adenoma (
30510241
)
Coronary artery disease (
29212778
33020668
)
Diverticular disease (
30177863
)
Heel bone mineral density (
30598549
)
Hen's egg allergy (
29051540
)
Maximum stenosis (
32469969
)
Polycystic ovary syndrome (reproductive subtype) (
32574161
)
Prepulse inhibition of the startle response (
31596458
)
Schizophrenia (
30470734
)
Sum of carotid plaque area (
32469969
)
Sum of stenosis (
32469969
)
Systolic blood pressure (
30224653
30578418
)
Waist-hip ratio (
28552196
)
Interacting Genes
64 interacting genes:
AMHR2
APP
ARHGEF6
BAMBI
BMP15
BMP2
BMP4
BMP6
BMP7
BMPR1A
BMPR2
CDK14
CDK4
CHN1
DCAF12
DCAF6
DCAF7
FANCL
GDF5
GDF6
GDF9
KLHL1
LZTR1
NKIRAS1
OTUB1
OXSR1
PAK1
PLEKHB1
POMK
PPP2CA
PPP3CC
RAB25
RAB38
RAB6B
RAN
RAP2A
RASD2
RASL12
RHEBL1
RHOD
RHOJ
RPS27A
RRAS2
SASH3
SH3KBP1
SMAD6
SMAD7
SNX6
SOCS6
SQSTM1
SRGAP1
STAMBP
STK35
STUB1
TGFBR1
TNNT1
TRAF6
TTC17
TTC27
UBA52
UBE2Z
UBXN1
USP45
VEPH1
5 interacting genes:
APP
BMPR1B
SMAD4
SMAD7
SMURF1
Entrez ID
658
54440
HPRD ID
04457
02342
Ensembl ID
ENSG00000138696
ENSG00000122122
Uniprot IDs
A8KAE3
O00238
O75995
PDB IDs
3MDY
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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