VPS18 and UVRAG

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		VPS18	UVRAG
Description		VPS18 core subunit of CORVET and HOPS complexes	UV radiation resistance associated
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Actin Filament AP-3 Adaptor Complex Clathrin-coated Vesicle HOPS Complex Late Endosome Membrane CORVET Complex Presynapse Glutamatergic Synapse	Lytic Vacuole Autophagosome Membrane Chromosome, Centromeric Region Cytoplasm Lysosome Endosome Early Endosome Late Endosome Endoplasmic Reticulum Centrosome Midbody Phagocytic Vesicle DNA-dependent Protein Kinase Complex
	Molecular Function	Actin Binding Protein Binding Syntaxin Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	SNARE Binding Protein Binding SH3 Domain Binding
	Biological Process	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Endosome Organization Vacuole Organization Lysosome Organization Endosome To Lysosome Transport Protein Ubiquitination Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of SNARE Complex Assembly Viral Entry Into Host Cell Regulation Of Synaptic Vesicle Exocytosis	DNA Repair Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Autophagy Spindle Organization Chromosome Segregation Centrosome Cycle Regulation Of Cytokinesis Receptor Catabolic Process SNARE Complex Assembly Viral Entry Into Host Cell Maintenance Of Golgi Location Regulation Of Protein Serine/threonine Kinase Activity Multivesicular Body Sorting Pathway Autophagosome Maturation Double-strand Break Repair Via Classical Nonhomologous End Joining Positive Regulation Of Autophagosome Maturation
Pathways			Macroautophagy Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs
Diseases
GWAS		Hemoglobin ( 32888494) Malaria ( 31844061) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Asthma ( 31619474) HDL cholesterol ( 30275531) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		20 interacting genes: AKTIP COPB1 EP300 GGA1 GGA2 GGA3 HOOK1 MON1B RAB7A RILP STX1A STX6 STX7 STX8 UBE2D2 UVRAG VPS11 VPS16 VPS33A VPS45	7 interacting genes: CSNK1A1 MTOR VPS11 VPS16 VPS18 VPS33B ZRANB1
Entrez ID		57617	7405
HPRD ID		09776	03929
Ensembl ID		ENSG00000104142	ENSG00000198382
Uniprot IDs		A0A024R9R3 Q9P253	Q9P2Y5
PDB IDs
Enriched GO Terms of Interacting Partners?
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