VPS18 and VPS33A

Data Source:
HPRD (in vivo)

		VPS18	VPS33A
Description		VPS18 core subunit of CORVET and HOPS complexes	VPS33A core subunit of CORVET and HOPS complexes
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Actin Filament AP-3 Adaptor Complex Clathrin-coated Vesicle HOPS Complex Late Endosome Membrane CORVET Complex Presynapse Glutamatergic Synapse	Lysosome Lysosomal Membrane Early Endosome Late Endosome Autophagosome AP-3 Adaptor Complex Clathrin-coated Vesicle HOPS Complex Late Endosome Membrane CORVET Complex Perinuclear Region Of Cytoplasm Clathrin Complex
	Molecular Function	Actin Binding Protein Binding Syntaxin Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Endosome Organization Vacuole Organization Lysosome Organization Endosome To Lysosome Transport Protein Ubiquitination Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of SNARE Complex Assembly Viral Entry Into Host Cell Regulation Of Synaptic Vesicle Exocytosis	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Endosome To Lysosome Transport Vesicle-mediated Transport Platelet Formation Melanosome Localization Lysosome Localization Regulation Of Lysosomal Lumen PH Regulation Of Developmental Pigmentation Autophagosome Maturation
Pathways
Drugs
Diseases
GWAS		Hemoglobin ( 32888494) Malaria ( 31844061) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		20 interacting genes: AKTIP COPB1 EP300 GGA1 GGA2 GGA3 HOOK1 MON1B RAB7A RILP STX1A STX6 STX7 STX8 UBE2D2 UVRAG VPS11 VPS16 VPS33A VPS45	7 interacting genes: MON1A MON1B ROPN1 TNKS VPS11 VPS16 VPS18
Entrez ID		57617	65082
HPRD ID		09776	15651
Ensembl ID		ENSG00000104142	ENSG00000139719
Uniprot IDs		A0A024R9R3 Q9P253	Q96AX1
PDB IDs			4BX8 4BX9
Enriched GO Terms of Interacting Partners?
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