PTGS2 and COPS7A

Data Source:
BioGRID (pull down)

		PTGS2	COPS7A
Description		prostaglandin-endoperoxide synthase 2	COP9 signalosome subunit 7A
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GO Annotations	Cellular Component	Nuclear Inner Membrane Nuclear Outer Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Neuron Projection	Nucleoplasm Cytosol COP9 Signalosome
	Molecular Function	Peroxidase Activity Prostaglandin-endoperoxide Synthase Activity Protein Binding Enzyme Binding Heme Binding Metal Ion Binding Dioxygenase Activity	Protein Binding
	Biological Process	Prostaglandin Biosynthetic Process Inflammatory Response Response To Oxidative Stress Regulation Of Blood Pressure Positive Regulation Of Vascular Endothelial Growth Factor Production Cytokine-mediated Signaling Pathway Cyclooxygenase Pathway Lipoxygenase Pathway Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Fever Generation NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Inflammatory Response Cellular Response To Hypoxia Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Fibroblast Growth Factor Production Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Platelet-derived Growth Factor Production Cellular Oxidant Detoxification Regulation Of Neuroinflammatory Response	Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Transcription-coupled Nucleotide-excision Repair COP9 Signalosome Assembly Viral Process Post-translational Protein Modification
Pathways		Nicotinamide salvaging Synthesis of 15-eicosatetraenoic acid derivatives Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Biosynthesis of DHA-derived SPMs Biosynthesis of EPA-derived SPMs Biosynthesis of DPAn-3 SPMs Biosynthesis of electrophilic Ï‰-3 PUFA oxo-derivatives	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs		Dihomo-gamma-linolenic acid Icosapent Aminosalicylic acid Mesalazine Acetaminophen Indomethacin Nabumetone Ketorolac Tenoxicam Lenalidomide Celecoxib Tolmetin Rofecoxib Piroxicam Fenoprofen Valdecoxib Diclofenac Sulindac Flurbiprofen Etodolac Mefenamic acid Naproxen Sulfasalazine Phenylbutazone Meloxicam Carprofen Diflunisal Suprofen Salicylic acid Meclofenamic acid Acetylsalicylic acid Bromfenac Oxaprozin Ketoprofen Balsalazide Thalidomide Ibuprofen Lumiracoxib Magnesium salicylate Salsalate Choline magnesium trisalicylate Ginseng Antrafenine Antipyrine Tiaprofenic acid Etoricoxib Flufenamic acid Resveratrol 1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole Prostaglandin G2 Niflumic acid Licofelone Nimesulide Cimicoxib Lornoxicam Aceclofenac Nepafenac Parecoxib Pomalidomide Cannabidiol Loxoprofen Dexibuprofen Dexketoprofen Droxicam Tolfenamic acid Firocoxib Morniflumate Propacetamol Talniflumate Phenyl salicylate Trolamine salicylate Menthyl salicylate Glycol salicylate Dipyrithione Bryostatin 1 Alclofenac Bufexamac Bendazac Acemetacin Fish oil Medical Cannabis Nabiximols
Diseases		Esophageal cancer Cholangiocarcinoma Penile cancer
GWAS		Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Knee osteoarthritis ( 18471798)	Red blood cell count ( 32888494)
Interacting Genes		13 interacting genes: ABHD16A CASK CAV1 CELF2 COPS5 COPS7A CTNNB1 ELAVL1 GAS5 NUCB1 PTGIS TP53 USP22	20 interacting genes: COPS2 COPS3 COPS4 COPS5 COPS8 CPEB2 CSNK2A1 CSNK2B CUL5 EIF3E GPS1 KRT19P3 NFE2L2 PMF1 PPBP PRKD1 PTGS2 RAF1 TOM1L1 TP53
Entrez ID		5743	50813
HPRD ID		02599	16736
Ensembl ID		ENSG00000073756	ENSG00000111652
Uniprot IDs		P35354	Q9UBW8
PDB IDs		1V0X 5F19 5F1A 5IKQ 5IKR 5IKT 5IKV 5KIR	4D10 4D18 4WSN
Enriched GO Terms of Interacting Partners?
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