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COPS7A and NFE2L2
Data Source:
HPRD
(in vitro)
COPS7A
NFE2L2
Description
COP9 signalosome subunit 7A
nuclear factor, erythroid 2 like 2
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytosol
COP9 Signalosome
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Plasma Membrane
Protein-DNA Complex
Molecular Function
Protein Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Activating Transcription Factor Binding
Transcription Coregulator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Domain Specific Binding
Sequence-specific DNA Binding
Biological Process
Protein Deneddylation
Nucleotide-excision Repair, DNA Damage Recognition
Transcription-coupled Nucleotide-excision Repair
COP9 Signalosome Assembly
Viral Process
Post-translational Protein Modification
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
Aging
Response To Lithium Ion
Proteasomal Ubiquitin-independent Protein Catabolic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Neuron Projection Development
Viral Process
Protein Ubiquitination
Positive Regulation Of Blood Coagulation
Endoplasmic Reticulum Unfolded Protein Response
Cellular Response To Oxidative Stress
Cellular Response To Drug
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
PERK-mediated Unfolded Protein Response
Cellular Response To Glucose Starvation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Cell Redox Homeostasis
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Embryonic Development
Aflatoxin Catabolic Process
Positive Regulation Of Glucose Import
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Response To Hydrogen Peroxide
Cellular Response To Copper Ion
Cellular Response To Tumor Necrosis Factor
Cellular Response To Fluid Shear Stress
Cellular Response To Laminar Fluid Shear Stress
Negative Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Positive Regulation Of Glutathione Biosynthetic Process
Cellular Response To Angiotensin
Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Regulation Of Removal Of Superoxide Radicals
Negative Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation
Drugs
Diseases
GWAS
Red blood cell count (
32888494
)
Estimated glomerular filtration rate (
31152163
31451708
30604766
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
HDL cholesterol levels (
32203549
)
Refractive error (
32231278
)
Interacting Genes
20 interacting genes:
COPS2
COPS3
COPS4
COPS5
COPS8
CPEB2
CSNK2A1
CSNK2B
CUL5
EIF3E
GPS1
KRT19P3
NFE2L2
PMF1
PPBP
PRKD1
PTGS2
RAF1
TOM1L1
TP53
37 interacting genes:
ATF4
BPTF
CASP1
CASP3
CDH1
CHD6
COPS7A
CREB3
CREBBP
DCAF11
EIF2AK3
GSK3B
JUN
JUND
KDM1A
KEAP1
KPNA3
MAFF
MAFG
MAFK
MAPK7
MAPK8
NCOR2
NFE2
NFE2L3
PAQR4
PMF1
PPARG
PRKCA
PRKCD
RBMX
SUMO1
SUMO2
TNNT1
TRIM24
UBE2E2
WAC
Entrez ID
50813
4780
HPRD ID
16736
02732
Ensembl ID
ENSG00000111652
ENSG00000116044
Uniprot IDs
Q9UBW8
Q16236
PDB IDs
4D10
4D18
4WSN
2FLU
2LZ1
3ZGC
4IFL
5WFV
6T7V
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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