NUP107 and NUP214

Data Source:
HPRD (in vivo)

		NUP107	NUP214
Description		nucleoporin 107	nucleoporin 214
Image
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nuclear Envelope Nuclear Pore Cytosol Membrane Nuclear Pore Outer Ring Nuclear Membrane Nuclear Periphery Host Cell	Nuclear Pore Nucleoplasm Cytosol Host Cell Cytoplasmic Side Of Nuclear Pore
	Molecular Function	Protein Binding Structural Constituent Of Nuclear Pore	Nuclear Export Signal Receptor Activity Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore
	Biological Process	Posttranscriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Regulation Of Glycolytic Process Regulation Of Transcription, DNA-templated MRNA Export From Nucleus TRNA Export From Nucleus Protein Import Into Nucleus Female Gonad Development Viral Process Protein Sumoylation Viral Transcription Nuclear Pore Complex Assembly Regulation Of Gene Silencing By MiRNA Nephron Development Intracellular Transport Of Virus Regulation Of Cellular Response To Heat	Mitotic Cell Cycle Regulation Of Glycolytic Process RNA Export From Nucleus MRNA Export From Nucleus TRNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Viral Process Protein Sumoylation Viral Transcription Regulation Of MRNA Stability Regulation Of Nucleocytoplasmic Transport Regulation Of Cell Cycle Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus Regulation Of Cellular Response To Heat
Pathways		ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins HuR (ELAVL1) binds and stabilizes mRNA SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events
Drugs
Diseases
GWAS		White blood cell count ( 20139978)	Aspartate aminotransferase levels ( 31219225)
Interacting Genes		3 interacting genes: NUP133 NUP214 SUMO2	20 interacting genes: APC CLEC4G DDX19B IPO5 NFX1 NUP107 NUP42 NUP62 NUP88 NXF1 NXF2 SMAD2 SMAD3 SMAD4 SUMO2 TNPO1 XPO1 XPO5 XPOT ZFP36
Entrez ID		57122	8021
HPRD ID		06356	00258
Ensembl ID		ENSG00000111581	ENSG00000126883
Uniprot IDs		P57740	B7ZAV2 P35658
PDB IDs		3CQC 3CQG 3I4R 5A9Q	2OIT 3FHC 3FMO 3FMP 5DIS
Enriched GO Terms of Interacting Partners?
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