NUP214 and ZFP36

Data Source:
BioGRID (pull down, two hybrid)
HPRD (two hybrid, in vivo)

		NUP214	ZFP36
Description		nucleoporin 214	ZFP36 ring finger protein
Image
GO Annotations	Cellular Component	Nuclear Pore Nucleoplasm Cytosol Host Cell Cytoplasmic Side Of Nuclear Pore	Exosome (RNase Complex) P-body Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule CCR4-NOT Complex RISC-loading Complex Ribonucleoprotein Complex
	Molecular Function	Nuclear Export Signal Receptor Activity Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore	DNA Binding RNA Binding MRNA Binding Protein Binding Enzyme Binding Protein Kinase Binding C-C Chemokine Binding Heat Shock Protein Binding MRNA 3'-UTR AU-rich Region Binding Protein-containing Complex Binding Metal Ion Binding RNA Polymerase Binding 14-3-3 Protein Binding
	Biological Process	Mitotic Cell Cycle Regulation Of Glycolytic Process RNA Export From Nucleus MRNA Export From Nucleus TRNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Viral Process Protein Sumoylation Viral Transcription Regulation Of MRNA Stability Regulation Of Nucleocytoplasmic Transport Regulation Of Cell Cycle Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus Regulation Of Cellular Response To Heat	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process Response To Wounding Regulation Of Keratinocyte Proliferation Viral Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-independent Decay Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Viral Transcription MiRNA Mediated Inhibition Of Translation P38MAPK Cascade Response To Starvation Regulation Of MRNA Stability Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Fat Cell Differentiation Regulation Of Keratinocyte Differentiation Negative Regulation Of Erythrocyte Differentiation MRNA Transport Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening 3'-UTR-mediated MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Cellular Response To Lipopolysaccharide Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Regulation Of Keratinocyte Apoptotic Process Negative Regulation Of Polynucleotide Adenylyltransferase Activity Positive Regulation Of Intracellular MRNA Localization Positive Regulation Of Gene Silencing By MiRNA
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins HuR (ELAVL1) binds and stabilizes mRNA SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events	Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 31219225)
Interacting Genes		20 interacting genes: APC CLEC4G DDX19B IPO5 NFX1 NUP107 NUP42 NUP62 NUP88 NXF1 NXF2 SMAD2 SMAD3 SMAD4 SUMO2 TNPO1 XPO1 XPO5 XPOT ZFP36	26 interacting genes: APP ATG16L1 CCDC85B CDK6 DCP1B DHX36 DNAJB1 EDC3 EXOSC6 EXOSC8 FHL3 HMGB1 HOXC9 MAPK1 MAPKAPK2 NCL NUP214 RUNX1T1 SFN TNF UPF2 XRN1 YWHAB YWHAG YWHAH ZDHHC17
Entrez ID		8021	7538
HPRD ID		00258	01835
Ensembl ID		ENSG00000126883	ENSG00000128016
Uniprot IDs		B7ZAV2 P35658	M0QY76 P26651
PDB IDs		2OIT 3FHC 3FMO 3FMP 5DIS	4J8S
Enriched GO Terms of Interacting Partners?
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