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RAD18 and RFC2
Data Source:
BioGRID
(enzymatic study)
RAD18
RFC2
Description
RAD18 E3 ubiquitin protein ligase
replication factor C subunit 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Replication Fork
Cytoplasm
Centrosome
Nuclear Body
Site Of Double-strand Break
Nuclear Inclusion Body
Rad6-Rad18 Complex
Nucleus
Nucleoplasm
DNA Replication Factor C Complex
Ctf18 RFC-like Complex
Molecular Function
Y-form DNA Binding
Damaged DNA Binding
Single-stranded DNA Binding
Protein Binding
Polyubiquitin Modification-dependent Protein Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein-containing Complex Binding
Metal Ion Binding
DNA Clamp Loader Activity
Protein Binding
ATP Binding
Single-stranded DNA Helicase Activity
Enzyme Binding
Biological Process
DNA Repair
Postreplication Repair
Protein Monoubiquitination
Cellular Response To DNA Damage Stimulus
Response To UV
Protein Ubiquitination
DNA Damage Response, Detection Of DNA Damage
Protein Autoubiquitination
Positive Regulation Of Chromosome Segregation
Negative Regulation Of Cell Death
DNA Replication
DNA-dependent DNA Replication
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Nucleotide-excision Repair, DNA Gap Filling
Translesion Synthesis
Telomere Maintenance Via Semi-conservative Replication
DNA Duplex Unwinding
Nucleotide-excision Repair, DNA Incision
Error-prone Translesion Synthesis
DNA Damage Response, Detection Of DNA Damage
Error-free Translesion Synthesis
Positive Regulation Of DNA-directed DNA Polymerase Activity
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
Recognition of DNA damage by PCNA-containing replication complex
E3 ubiquitin ligases ubiquitinate target proteins
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Polymerase switching on the C-strand of the telomere
Activation of ATR in response to replication stress
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Regulation of TP53 Activity through Phosphorylation
Polymerase switching
G2/M DNA damage checkpoint
Drugs
Diseases
GWAS
Chronotype (
30696823
)
Clopidogrel active metabolite levels (
28207573
)
Metabolite levels (
23823483
)
Morning person (
30696823
)
Sleep duration (
30531941
)
Transverse temporal cortex volume (
31530798
)
Interacting Genes
30 interacting genes:
ARRDC3
DAZAP2
DZIP3
GOLGA2
MAGEA4
MAP3K1
MAPK8
MLKL
NBN
ORC2
PCGF6
PCNA
PDCD5
POLK
RAD51
RFC2
SHPRH
SIVA1
TAX1BP1
TP53BP1
TRIM23
TRIM8
TSG101
UBC
UBE2A
UBE2B
UBE2D2
UBE2I
USP2
USP7
12 interacting genes:
HGS
PCNA
PRKAR1A
PSMA1
RAD17
RAD18
RFC1
RFC4
RFC5
SUMO2
YOD1
ZIC1
Entrez ID
56852
5982
HPRD ID
09242
02675
Ensembl ID
ENSG00000070950
ENSG00000049541
Uniprot IDs
Q9NS91
A0A087WVY3
P35250
Q75MT5
PDB IDs
2MRE
2MRF
2Y43
2YBF
5VF0
6VVO
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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