TMPRSS15 and M6PR

Data Source:
BioGRID (affinity chromatography technology)

		TMPRSS15	M6PR
Description		transmembrane serine protease 15	mannose-6-phosphate receptor, cation dependent
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GO Annotations	Cellular Component	Brush Border Membrane Integral Component Of Membrane	Lysosomal Membrane Endosome Late Endosome Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Membrane Transport Vesicle Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Serine-type Endopeptidase Activity Scavenger Receptor Activity Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Protein Domain Specific Binding Retromer Complex Binding
	Biological Process	Proteolysis Endocytosis	Protein Targeting To Lysosome Receptor-mediated Endocytosis Lysosomal Transport Endosome To Lysosome Transport Secretion Of Lysosomal Enzymes Membrane Organization
Pathways			Lysosome Vesicle Biogenesis Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Alglucosidase alfa 1-3 Sugar Ring of Pentamannosyl 6-Phosphate alpha-D-mannose 6-phosphate
Diseases		Enterokinase deficiency
GWAS		Asthma ( 29273806) Bulimia nervosa ( 23568457) Nucleus accumbens volume in trauma-exposed individuals ( 29187748)	SjÃ¶gren's syndrome ( 28076899) Total cholesterol levels ( 30275531)
Interacting Genes		1 interacting genes: SPINK1	12 interacting genes: DUSP12 GGA1 GGA2 GGA3 GIMAP5 HSPA12A JUN KTN1 NINJ2 PLIN3 REN SMCO4
Entrez ID		5651	4074
HPRD ID		05972	01106
Ensembl ID		ENSG00000154646	ENSG00000003056
Uniprot IDs		P98073	F5GX30 P20645
PDB IDs		4DGJ 6ZOV	1JUQ
Enriched GO Terms of Interacting Partners?
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