TMPRSS15 and SPINK1

		TMPRSS15	SPINK1
Description		transmembrane serine protease 15	serine peptidase inhibitor Kazal type 1
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GO Annotations	Cellular Component	Brush Border Membrane Integral Component Of Membrane	Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Scavenger Receptor Activity Protein Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Proteolysis Endocytosis	Negative Regulation Of Nitric Oxide Mediated Signal Transduction Sperm Capacitation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Acrosome Reaction Negative Regulation Of Calcium Ion Import Negative Regulation Of Serine-type Endopeptidase Activity Regulation Of Store-operated Calcium Entry
Pathways
Drugs
Diseases		Enterokinase deficiency	Tropical calcific pancreatitis Hereditary pancreatitis; Hereditary chronic pancreatitis
GWAS		Asthma ( 29273806) Bulimia nervosa ( 23568457) Nucleus accumbens volume in trauma-exposed individuals ( 29187748)	Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576) Metabolite levels ( 23823483) Obesity-related traits ( 23251661)
Interacting Genes		1 interacting genes: SPINK1	6 interacting genes: ASPH CTRC ELN NRSN1 TMPRSS15 UBE3A
Entrez ID		5651	6690
HPRD ID		05972	01341
Ensembl ID		ENSG00000154646	ENSG00000164266
Uniprot IDs		P98073	P00995
PDB IDs		4DGJ 6ZOV	1CGI 1CGJ 1HPT
Enriched GO Terms of Interacting Partners?
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