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M6PR

Description mannose-6-phosphate receptor, cation dependent
Image
GO Annotations Cellular Component
  • Lysosomal Membrane
  • Endosome
  • Late Endosome
  • Trans-Golgi Network
  • Plasma Membrane
  • Integral Component Of Plasma Membrane
  • Membrane
  • Transport Vesicle
  • Clathrin-coated Vesicle Membrane
  • Trans-Golgi Network Membrane
  • Perinuclear Region Of Cytoplasm
Molecular Function
  • Transmembrane Signaling Receptor Activity
  • Protein Binding
  • Protein Domain Specific Binding
  • Retromer Complex Binding
Biological Process
  • Protein Targeting To Lysosome
  • Receptor-mediated Endocytosis
  • Lysosomal Transport
  • Endosome To Lysosome Transport
  • Secretion Of Lysosomal Enzymes
  • Membrane Organization
Pathways
  • Lysosome Vesicle Biogenesis
  • Retrograde transport at the Trans-Golgi-Network
  • Cargo recognition for clathrin-mediated endocytosis
  • Clathrin-mediated endocytosis
Drugs
  • Alglucosidase alfa
  • 1-3 Sugar Ring of Pentamannosyl 6-Phosphate
  • alpha-D-mannose 6-phosphate
Diseases
GWAS
  • Sjögren's syndrome ( 28076899)
  • Total cholesterol levels ( 30275531)
Novel Interacting Genes 1 novel interacting genes: TMPRSS15
Interacting Genes 12 interacting genes: DUSP12 GGA1 GGA2 GGA3 GIMAP5 HSPA12A JUN KTN1 NINJ2 PLIN3 REN SMCO4
Entrez ID 4074
HPRD ID 01106
Ensembl ID ENSG00000003056
Uniprot IDs F5GX30 P20645
PDB IDs 1JUQ
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025