PRM1 and LBR

Data Source:
HPRD (in vitro)

		PRM1	LBR
Description		protamine 1	lamin B receptor
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GO Annotations	Cellular Component	Nucleosome Nucleoplasm Cytosol	Nucleus Nuclear Envelope Nuclear Inner Membrane Integral Component Of Nuclear Inner Membrane Cytoplasm Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Nuclear Membrane
	Molecular Function	DNA Binding Protein Binding	DNA Binding RNA Binding Protein Binding Lamin Binding Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Delta14-sterol Reductase Activity Chromo Shadow Domain Binding NADPH Binding
	Biological Process	DNA Packaging Multicellular Organism Development Spermatogenesis Cell Differentiation Chromosome Condensation	Cholesterol Biosynthetic Process Sterol Biosynthetic Process Neutrophil Differentiation
Pathways			Cholesterol biosynthesis Initiation of Nuclear Envelope (NE) Reformation Regulation of MECP2 expression and activity
Drugs
Diseases			HEM skeletal dysplasia; Greenberg dysplasia Pelger-Huet anomaly
GWAS		Asthma ( 31959851) Bulimia nervosa ( 23568457) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Multiple sclerosis ( 31604244 22190364) Multiple sclerosis and type 2 diabetes (pleiotropy) ( 26920376) Obesity-related traits ( 23251661) Primary biliary cirrhosis ( 22961000)	Delirium ( 29631748) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		3 interacting genes: CLK2 LBR SRPK1	12 interacting genes: AKAP8L CBX3 CBX5 CD81 FNBP4 H4C14 LMNB1 MECP2 PRM1 SRPK1 SRPK2 YWHAG
Entrez ID		5619	3930
HPRD ID		01688	02488
Ensembl ID		ENSG00000175646	ENSG00000143815
Uniprot IDs		P04553 Q3MN80	Q14739
PDB IDs		2AWR	2DIG
Enriched GO Terms of Interacting Partners?
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