PRM1 and CLK2

Data Source:
BioGRID (two hybrid)

		PRM1	CLK2
Description		protamine 1	CDC like kinase 2
Image
GO Annotations	Cellular Component	Nucleosome Nucleoplasm Cytosol	Nucleus Nucleoplasm Nuclear Body Nuclear Speck
	Molecular Function	DNA Binding Protein Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	DNA Packaging Multicellular Organism Development Spermatogenesis Cell Differentiation Chromosome Condensation	Protein Phosphorylation Response To Ionizing Radiation Peptidyl-tyrosine Phosphorylation Regulation Of RNA Splicing Negative Regulation Of Gluconeogenesis Protein Autophosphorylation
Pathways
Drugs			Fostamatinib
Diseases
GWAS		Asthma ( 31959851) Bulimia nervosa ( 23568457) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Multiple sclerosis ( 31604244 22190364) Multiple sclerosis and type 2 diabetes (pleiotropy) ( 26920376) Obesity-related traits ( 23251661) Primary biliary cirrhosis ( 22961000)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		3 interacting genes: CLK2 LBR SRPK1	53 interacting genes: AKT1 ASPSCR1 CACTIN CLASRP CLK1 CLK3 CPSF7 DDIT4L ECE1 EHHADH GMCL1 GTPBP2 KLHL2 LNX1 LUZP4 MRPL4 NXF1 PRM1 PRPF38A PTPN1 RBM39 RNF8 RNPS1 RSRP1 SDCBP SNIP1 SNRNP70 SRPK2 SRRM1 SRSF3 TACC2 TRIM27 TRIM50 U2AF1 UBE2I UBL5 YTHDC1 YWHAG ZNF136 ZNF263 ZNF317 ZNF394 ZNF398 ZNF436 ZNF440 ZNF473 ZNF491 ZNF558 ZNF764 ZNF768 ZNF837 ZRSR2 ZSCAN21
Entrez ID		5619	1196
HPRD ID		01688	04289
Ensembl ID		ENSG00000175646	ENSG00000176444
Uniprot IDs		P04553 Q3MN80	A8K7I0 B7Z8N6 P49760
PDB IDs		2AWR	3NR9 5UNP 6FYI 6FYK 6FYL 6KHE
Enriched GO Terms of Interacting Partners?
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