TEX11 and ATXN3

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TEX11	ATXN3
Description		testis expressed 11	ataxin 3
Image		No pdb structure
GO Annotations	Cellular Component	Synaptonemal Complex Central Element Chromosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrial Matrix Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Nuclear Matrix Mitochondrial Membrane Nuclear Inclusion Body Synapse
	Molecular Function	Protein Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Ubiquitin Protein Ligase Binding ATPase Binding Lys63-specific Deubiquitinase Activity Lys48-specific Deubiquitinase Activity
	Biological Process	Resolution Of Meiotic Recombination Intermediates Meiotic Gene Conversion Male Meiosis Chromosome Segregation Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Gonad Development Fertilization Negative Regulation Of Apoptotic Process Chiasma Assembly	Microtubule Cytoskeleton Organization Nucleotide-excision Repair Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Chemical Synaptic Transmission Nervous System Development Regulation Of Cell-substrate Adhesion Protein Deubiquitination Protein Phosphopantetheinylation Actin Cytoskeleton Organization Cellular Response To Heat Monoubiquitinated Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Cytoskeleton Organization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Misfolded Protein Positive Regulation Of ERAD Pathway Protein Localization To Cytosolic Proteasome Complex Involved In ERAD Pathway
Pathways			Josephin domain DUBs FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Mean corpuscular volume ( 29403010) Waist circumference ( 28552196)	Amyotrophic lateral sclerosis ( 29566793) Coronary artery calcification ( 23870195) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Height ( 18391950 18391951) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Orofacial clefts ( 22419666) Refractive error ( 32231278)
Interacting Genes		91 interacting genes: ATXN3 BCL2L2 BEX1 BORCS8 BORCS8-MEF2B BRMS1L C10orf82 C2CD6 C6orf226 CBY2 CCDC198 CCND2 CCND3 CD74 CDKN1A CDKN2D CENPP CEP55 CEP85L CFAP53 CLK1 CNOT7 COL20A1 CXCL14 DMTN DUSP21 DUSP6 EFHC1 EXOSC1 EXOSC5 FAAP20 FAM156A FAM161B FAM217A FBF1 GATAD2B GPSM3 GRXCR1 HOXB5 HYI ING3 KANK2 KCTD10 KIAA0408 KIAA1217 KRT6B LIN37 LRCH2 LRRC36 LSM2 MAD1L1 MAPK9 MAPKBP1 MORF4L1 MRFAP1 MRFAP1L1 MTA1 MYEF2 NECAB2 NEFL NRIP1 PIAS1 POM121 PPP1R18 PRPSAP2 PTPDC1 QKI REXO1L6P RIBC1 RIBC2 SCAF8 SEPTIN1 SH3GLB2 SHOC1 SNW1 SNX32 SNX6 SNX7 SOX5 STMN2 SUPT5H TBC1D22B TCHP TIPIN TOPBP1 TSC22D4 TSG101 USP15 UTP14C VIL1 ZNF414	53 interacting genes: ANXA7 APP ARHGAP19 ARHGDIA ASIC1 CAPN1 CAPN2 CASP1 CDKN1A CHEK1 CSNK2B DNM2 EWSR1 GABARAP GSK3B HDAC6 KAT2B MAP1LC3A MAP1LC3C MAP3K1 MKNK1 NCOR1 NEDD8 PHAF1 PICK1 PJA1 PRKN PSMD7 RAD23A RAD23B RFFL RPS6KA1 SMURF1 SQSTM1 STUB1 SUMO1 TEX11 TK1 TP53 TRAF6 TRIM54 TRIM55 TRIM63 TUBA1A TUBB UBB UBC UBE2L3 UBE2S UBE4B UBQLN1 USP21 VCP
Entrez ID		56159	4287
HPRD ID		02256	06131
Ensembl ID		ENSG00000120498	ENSG00000066427
Uniprot IDs		Q8IYF3	A0A0A0MS38 C9JQV6 P54252
PDB IDs			1YZB 2AGA 2DOS 2JRI 2KLZ 4WTH 4YS9
Enriched GO Terms of Interacting Partners?
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