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ATXN3 and UBE2S
Data Source:
BioGRID
(enzymatic study)
ATXN3
UBE2S
Description
ataxin 3
ubiquitin conjugating enzyme E2 S
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrial Matrix
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Nuclear Matrix
Mitochondrial Membrane
Nuclear Inclusion Body
Synapse
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Molecular Function
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Cysteine-type Peptidase Activity
Ubiquitin Protein Ligase Binding
ATPase Binding
Lys63-specific Deubiquitinase Activity
Lys48-specific Deubiquitinase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Anaphase-promoting Complex Binding
Ubiquitin Conjugating Enzyme Activity
Biological Process
Microtubule Cytoskeleton Organization
Nucleotide-excision Repair
Ubiquitin-dependent Protein Catabolic Process
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
Chemical Synaptic Transmission
Nervous System Development
Regulation Of Cell-substrate Adhesion
Protein Deubiquitination
Protein Phosphopantetheinylation
Actin Cytoskeleton Organization
Cellular Response To Heat
Monoubiquitinated Protein Deubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Intermediate Filament Cytoskeleton Organization
Protein K63-linked Deubiquitination
Protein K48-linked Deubiquitination
Cellular Response To Misfolded Protein
Positive Regulation Of ERAD Pathway
Protein Localization To Cytosolic Proteasome Complex Involved In ERAD Pathway
Protein Polyubiquitination
Cellular Protein Modification Process
Ubiquitin-dependent Protein Catabolic Process
Exit From Mitosis
Free Ubiquitin Chain Polymerization
Protein Ubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
Protein K29-linked Ubiquitination
Protein K27-linked Ubiquitination
Cell Division
Protein K63-linked Ubiquitination
Protein K11-linked Ubiquitination
Protein K6-linked Ubiquitination
Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways
Josephin domain DUBs
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS
Amyotrophic lateral sclerosis (
29566793
)
Coronary artery calcification (
23870195
)
HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction (
31806883
)
Height (
18391950
18391951
)
LDL cholesterol levels x loop diuretics use interaction (
31806883
)
Orofacial clefts (
22419666
)
Refractive error (
32231278
)
Interacting Genes
53 interacting genes:
ANXA7
APP
ARHGAP19
ARHGDIA
ASIC1
CAPN1
CAPN2
CASP1
CDKN1A
CHEK1
CSNK2B
DNM2
EWSR1
GABARAP
GSK3B
HDAC6
KAT2B
MAP1LC3A
MAP1LC3C
MAP3K1
MKNK1
NCOR1
NEDD8
PHAF1
PICK1
PJA1
PRKN
PSMD7
RAD23A
RAD23B
RFFL
RPS6KA1
SMURF1
SQSTM1
STUB1
SUMO1
TEX11
TK1
TP53
TRAF6
TRIM54
TRIM55
TRIM63
TUBA1A
TUBB
UBB
UBC
UBE2L3
UBE2S
UBE4B
UBQLN1
USP21
VCP
42 interacting genes:
AKT1
ANAPC1
ANAPC11
ANAPC2
ANAPC4
ANAPC5
ANAPC7
APP
ATXN3
BIRC2
CCNB1
CDC16
CDC20
CDC23
CDC27
CTNNB1
CYLD
FBXO5
FZR1
GMNN
HERC1
LINC00839
MDM2
OTUB1
OTUD7B
PRKN
PTEN
RBCK1
RNF7
STAMBP
UBA1
UBA6
UBB
UBC
UCHL3
USP15
USP2
USP21
USP5
USP7
VHL
ZRANB1
Entrez ID
4287
27338
HPRD ID
06131
15603
Ensembl ID
ENSG00000066427
ENSG00000108106
Uniprot IDs
A0A0A0MS38
C9JQV6
P54252
Q16763
PDB IDs
1YZB
2AGA
2DOS
2JRI
2KLZ
4WTH
4YS9
1ZDN
5BNB
5L9T
6QH3
6QHK
6S96
6S98
Enriched GO Terms of Interacting Partners
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