MAP2K3 and DYRK1B

Data Source:
HPRD (in vivo)

		MAP2K3	DYRK1B
Description		mitogen-activated protein kinase kinase 3	dual specificity tyrosine phosphorylation regulated kinase 1B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Membrane	Nucleus Nucleoplasm Chromosome
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding	Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Activation Of MAPK Activity Regulation Of Cytokine Production Inflammatory Response Signal Transduction Peptidyl-tyrosine Phosphorylation Negative Regulation Of Hippo Signaling Cellular Response To Vascular Endothelial Growth Factor Stimulus P38MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Cardiac Muscle Contraction	Protein Phosphorylation Myoblast Fusion Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Adipose Tissue Development
Pathways		Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation
Drugs		Fostamatinib	Fostamatinib
Diseases
GWAS		Body mass index ( 26426971 28892062)	Macular thickness ( 30535121)
Interacting Genes		54 interacting genes: AKT1 ALDOC APP ARAF ARRB1 AURKA BECN1 BRAF CBLC CCND2 CD44 CDC42 CDK4 CDK6 CDKN2B CDKN2C DCTN1 DYRK1B ELK1 ERBB2 FZR1 GLIS2 HIF1A KAT2A KDELR2 LATS2 LRRK2 MAP2K5 MAP2K6 MAP3K2 MAP3K3 MAP3K4 MAPK12 MAPK14 MAPK3 MAPK8IP2 MET NF1 NF2 NFIC PLCB2 PTEN RAF1 RASSF1 RPL13 SMAD1 SMAD7 STK11 TAOK1 TAOK2 TEAD2 TERT TINF2 TP53	12 interacting genes: DCAF7 GSC2 HDAC5 ID2 MAP2K3 MAPK1 MAPK14 MBP PAK1 PCBD1 RANBP9 TROAP
Entrez ID		5606	9149
HPRD ID		03816	05188
Ensembl ID		ENSG00000034152	ENSG00000105204
Uniprot IDs		P46734 Q6FI23	A0A024R0I0 A0A024R0J6 A0A024R0M8 Q9Y463
PDB IDs
Enriched GO Terms of Interacting Partners?
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