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MAP2K3 and PLCB2
Data Source:
BioGRID
(two hybrid, affinity chromatography technology)
HPRD
(in vivo, two hybrid)
MAP2K3
PLCB2
Description
mitogen-activated protein kinase kinase 3
phospholipase C beta 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Cytosol
Membrane
Cytosol
Molecular Function
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Phosphatidylinositol Phospholipase C Activity
Phospholipase C Activity
Calcium Ion Binding
Protein Binding
Biological Process
Activation Of MAPK Activity
Regulation Of Cytokine Production
Inflammatory Response
Signal Transduction
Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Hippo Signaling
Cellular Response To Vascular Endothelial Growth Factor Stimulus
P38MAPK Cascade
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Transcription, DNA-templated
Cardiac Muscle Contraction
Phospholipid Metabolic Process
G Protein-coupled Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Wnt Signaling Pathway, Calcium Modulating Pathway
Lipid Catabolic Process
Inositol Phosphate Metabolic Process
Phosphatidylinositol Metabolic Process
Phosphatidylinositol-mediated Signaling
Sensory Perception Of Bitter Taste
Pathways
Oxidative Stress Induced Senescence
activated TAK1 mediates p38 MAPK activation
PLC beta mediated events
PLC beta mediated events
Synthesis of IP3 and IP4 in the cytosol
Acetylcholine regulates insulin secretion
Acetylcholine regulates insulin secretion
Ca2+ pathway
G alpha (q) signalling events
G alpha (q) signalling events
G beta:gamma signalling through PLC beta
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Presynaptic function of Kainate receptors
Drugs
Fostamatinib
Diseases
GWAS
Body mass index (
26426971
28892062
)
Chronic kidney disease (
30226566
)
Coronary artery disease (
30402224
)
Hypertension (
30226566
)
Ischemic stroke (
29930801
)
Myocardial infarction (
30226566
)
Neutrophil count (
32888494
)
Schizophrenia (
25056061
29483656
)
White blood cell count (
32888494
)
Interacting Genes
54 interacting genes:
AKT1
ALDOC
APP
ARAF
ARRB1
AURKA
BECN1
BRAF
CBLC
CCND2
CD44
CDC42
CDK4
CDK6
CDKN2B
CDKN2C
DCTN1
DYRK1B
ELK1
ERBB2
FZR1
GLIS2
HIF1A
KAT2A
KDELR2
LATS2
LRRK2
MAP2K5
MAP2K6
MAP3K2
MAP3K3
MAP3K4
MAPK12
MAPK14
MAPK3
MAPK8IP2
MET
NF1
NF2
NFIC
PLCB2
PTEN
RAF1
RASSF1
RPL13
SMAD1
SMAD7
STK11
TAOK1
TAOK2
TEAD2
TERT
TINF2
TP53
7 interacting genes:
GNAQ
MAP2K3
MAP2K6
SLC9A3R1
SNCA
TRPC3
TRPM7
Entrez ID
5606
5330
HPRD ID
03816
04985
Ensembl ID
ENSG00000034152
ENSG00000137841
Uniprot IDs
P46734
Q6FI23
Q00722
Q59F77
Q9BVT6
PDB IDs
2FJU
2ZKM
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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