USE1 and BSCL2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		USE1	BSCL2
Description		unconventional SNARE in the ER 1	BSCL2 lipid droplet biogenesis associated, seipin
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Membrane COPI-coated Vesicle SNARE Complex	Endoplasmic Reticulum Membrane Lipid Droplet Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	SNAP Receptor Activity Protein Binding	Protein Binding Phospholipid Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Lysosomal Transport Protein Transport Protein Catabolic Process Secretion By Cell Membrane Fusion	Lipid Catabolic Process Lipid Storage Lipid Droplet Organization Fat Cell Differentiation Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Cold-induced Thermogenesis Lipid Droplet Formation
Pathways		COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases			Hereditary spastic paraplegia (SPG) Congenital generalized lipodystrophy (CGL) Distal hereditary motor neuropathies (dHMN)
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Night sleep phenotypes ( 27126917)	Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		18 interacting genes: APOL2 APP AQP6 BSCL2 CALN1 CCDC70 CCM2L CREB3 EBP JAGN1 LMNA MEOX2 MFSD14B SCN3B STX1A STX4 TMEM86B TRIM27	38 interacting genes: ANKRD46 B4GALNT2 BMP10 CLDN19 CMTM7 CPEB2 CXCL9 CYSRT1 ERMP1 FAM20B GABARAPL1 GMCL1 HOXA1 KRTAP6-3 LAT MALL NSG1 OLFM4 PLEKHF2 PLIN1 RPRM SERP1 SERP2 SFTPC SMIM3 SMLR1 STRIT1 TEX37 TMEM19 TMEM218 TMEM222 TRAM1L1 TRARG1 TRIM54 TSPAN2 UPK2 USE1 VAMP3
Entrez ID		55850	26580
HPRD ID		11299	05858
Ensembl ID		ENSG00000053501	ENSG00000168000
Uniprot IDs		Q9NZ43	A0A024R540 A0A024R549 Q96G97
PDB IDs			6DS5
Enriched GO Terms of Interacting Partners?
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