KIF16B and PRKAA1

Data Source:
BioGRID (two hybrid)

		KIF16B	PRKAA1
Description		kinesin family member 16B	protein kinase AMP-activated catalytic subunit alpha 1
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Spindle Cytosol Kinesin Complex Microtubule Early Endosome Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Apical Plasma Membrane Nuclear Speck Axon Dendrite Nucleotide-activated Protein Kinase Complex Neuronal Cell Body
	Molecular Function	Microtubule Motor Activity ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Histone Serine Kinase Activity Protein-containing Complex Binding Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Tau Protein Binding Tau-protein Kinase Activity [acetyl-CoA Carboxylase] Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Formation Of Primary Germ Layer Regulation Of Receptor Recycling Golgi To Endosome Transport Microtubule-based Movement Epidermal Growth Factor Receptor Signaling Pathway Endoderm Development Fibroblast Growth Factor Receptor Signaling Pathway Receptor Catabolic Process Early Endosome To Late Endosome Transport	Activation Of MAPK Activity Response To Hypoxia Glucose Metabolic Process Protein Phosphorylation Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Cell Cycle Arrest Signal Transduction Positive Regulation Of Cell Population Proliferation Lipid Biosynthetic Process Response To UV Cold Acclimation Response To Gamma Radiation Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Response To Activity Bile Acid And Bile Salt Transport Wnt Signaling Pathway Macroautophagy Regulation Of Macroautophagy Fatty Acid Oxidation Response To Caffeine Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Oxidative Stress Histone-serine Phosphorylation Intracellular Signal Transduction Cellular Response To Drug Bile Acid Signaling Pathway Cellular Response To Glucose Starvation Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Glycolytic Process Negative Regulation Of Glucosylceramide Biosynthetic Process Negative Regulation Of Insulin Receptor Signaling Pathway Rhythmic Process Positive Regulation Of Skeletal Muscle Tissue Development Negative Regulation Of Lipid Catabolic Process Fatty Acid Homeostasis Regulation Of Vesicle-mediated Transport Motor Behavior CAMKK-AMPK Signaling Cascade Regulation Of Stress Granule Assembly Neuron Cellular Homeostasis Cellular Response To Hydrogen Peroxide Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Calcium Ion Cellular Response To Glucose Stimulus Cellular Response To Ethanol Cellular Response To Prostaglandin E Stimulus Cellular Response To Organonitrogen Compound Cellular Response To Hypoxia Energy Homeostasis Regulation Of Bile Acid Secretion Response To Camptothecin Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Mitochondrial Transcription Positive Regulation Of Cellular Protein Localization Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Tubulin Deacetylation Response To 17alpha-ethynylestradiol Positive Regulation Of Peptidyl-lysine Acetylation
Pathways		COPI-dependent Golgi-to-ER retrograde traffic Kinesins	Macroautophagy Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Activation of AMPK downstream of NMDARs
Drugs			Adenosine phosphate Adenosine phosphate ATP Phenformin Acetylsalicylic acid Fostamatinib Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Asthma ( 27611488) Body mass index ( 26426971) Chronotype ( 30696823) Dimensional psychopathology (Positive) ( 29496196) Emphysema imaging phenotypes ( 26030696) Gut microbiota alpha diversity (Chao1 index) ( 33208821) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Gut microbiota alpha diversity (Shannon index) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821) Ileal carcinoids ( 21139019) Intelligence ( 22449649) Lipid traits ( 30576415) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Sweet taste preference ( 32572145)	Cardia gastric cancer ( 26129866) Gastric cancer ( 22037551 26098866 26129866 31383772) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Non-cardia gastric cancer ( 26701879 26129866)
Interacting Genes		10 interacting genes: GABARAPL2 GINS4 IL16 ITSN1 LGALS3 PRKAA1 PRKAA2 SMYD1 TCEANC TSR2	67 interacting genes: ABI2 ACACA BHLHE40 CAB39 CAMKK1 CDX4 CFTR CHEK1 CRTC2 CTBP1 DVL2 EEF2K EPM2A FANCA FNIP1 GATA1 GOLGA2 GRIK2 HDAC5 HMBOX1 HOMEZ IKZF3 INO80E KIF16B KRT40 L3MBTL3 MDM4 MORC4 MTOR MTUS2 PASK PFKFB2 PHC2 PNMA5 PPM1A PPM1E PPM1F PPP2CA PRKAB1 PRKAB2 PRKAG1 PRKAG3 PSMD11 RACK1 RAD54B RAF1 RBPMS RFX6 RIMBP3 ROPN1 RPTOR SRPK2 SSX2IP STK11 THAP1 TLE5 TOMM34 TRIM27 TRIP6 TSC2 TSC22D4 TXNIP UBXN11 ULK1 VPS37B VPS52 ZBED1
Entrez ID		55614	5562
HPRD ID		10731	04115
Ensembl ID		ENSG00000089177	ENSG00000132356
Uniprot IDs		A0A140VK74 A0A1B0GTU3 Q96L93	Q13131
PDB IDs		2V14 6EE0	4RED 4RER 4REW 5EZV 6C9F 6C9G 6C9H 6C9J
Enriched GO Terms of Interacting Partners?
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