PRF1 and DDX24

Data Source:
HPRD (two hybrid)

		PRF1	DDX24
Description		perforin 1	DEAD-box helicase 24
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Membrane Integral Component Of Membrane Endosome Lumen Cytolytic Granule	Nucleolus Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Wide Pore Channel Activity Identical Protein Binding	RNA Binding RNA Helicase Activity ATP Binding
	Biological Process	Immunological Synapse Formation T Cell Mediated Cytotoxicity Defense Response To Tumor Cell Immune Response To Tumor Cell Apoptotic Process Cellular Defense Response Cytolysis Protein Homooligomerization Defense Response To Virus Positive Regulation Of Killing Of Cells Of Other Organism Transmembrane Transport	RNA Metabolic Process
Pathways
Drugs
Diseases		Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency
GWAS		Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Multiple keratinocyte cancers ( 28081215) Obesity (extreme) ( 19553259)	Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		8 interacting genes: CALR CYSRT1 DDX24 GZMB KRT31 NBPF19 NOTCH2NLA TRIM54	34 interacting genes: BCS1L BRCA1 CSNK2A1 EIF3E EP300 FADD GIT1 GLRA2 HSP90AB1 HSPA5 IDO1 ITGB3BP LMNA MDM2 MKS1 MRPL4 NRXN2 PAFAH1B3 PIN1 POLA2 PRF1 PTEN PTPN23 RAE1 SPACA9 SPTAN1 TERF1 TERF2 TERF2IP TMEM9B TPI1 TRDMT1 UBE2I VDAC3
Entrez ID		5551	57062
HPRD ID		01362	05860
Ensembl ID		ENSG00000180644	ENSG00000089737
Uniprot IDs		P14222	Q9GZR7
PDB IDs
Enriched GO Terms of Interacting Partners?
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