PRF1

Description		perforin 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Membrane Integral Component Of Membrane Endosome Lumen Cytolytic Granule
	Molecular Function	Calcium Ion Binding Protein Binding Wide Pore Channel Activity Identical Protein Binding
	Biological Process	Immunological Synapse Formation T Cell Mediated Cytotoxicity Defense Response To Tumor Cell Immune Response To Tumor Cell Apoptotic Process Cellular Defense Response Cytolysis Protein Homooligomerization Defense Response To Virus Positive Regulation Of Killing Of Cells Of Other Organism Transmembrane Transport
Pathways
Drugs
Diseases		Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency
GWAS		Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Multiple keratinocyte cancers ( 28081215) Obesity (extreme) ( 19553259)
Interacting Genes		8 interacting genes: CALR CYSRT1 DDX24 GZMB KRT31 NBPF19 NOTCH2NLA TRIM54
Entrez ID		5551
HPRD ID		01362
Ensembl ID		ENSG00000180644
Uniprot IDs		P14222
PDB IDs
Enriched GO Terms of Interacting Partners?
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