PRELP and COL2A1

Data Source:
HPRD (in vitro)

		PRELP	COL2A1
Description		proline and arginine rich end leucine rich repeat protein	collagen type II alpha 1 chain
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Extracellular Vesicle	Extracellular Region Collagen Trimer Collagen Type II Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Heparin Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength MHC Class II Protein Binding Identical Protein Binding Proteoglycan Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Skeletal System Development Cell Aging Keratan Sulfate Biosynthetic Process Keratan Sulfate Catabolic Process	Skeletal System Development Cartilage Condensation Tissue Homeostasis Endochondral Ossification Chondrocyte Differentiation Heart Morphogenesis Proteoglycan Metabolic Process Central Nervous System Development Visual Perception Sensory Perception Of Sound Regulation Of Gene Expression Extracellular Matrix Organization Collagen Fibril Organization Notochord Development Inner Ear Morphogenesis Regulation Of Immune Response Cartilage Development Roof Of Mouth Development Limb Bud Formation Embryonic Skeletal Joint Morphogenesis Cartilage Development Involved In Endochondral Bone Morphogenesis Otic Vesicle Development Cellular Response To BMP Stimulus Anterior Head Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Keratan sulfate biosynthesis Keratan sulfate degradation Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization
Drugs			Collagenase clostridium histolyticum
Diseases			Type II collagenopathies, including: Achondrogenesis II; Hypochondrogenesis; SED congenita; SMED Strudwick type; Kniest dysplasia; Spondyloperipheral dysplasia; Osteoarthritis with mild chondrodysplasia; Stickler syndrome 1; Platyspondylic skeletal dysplasia, Torrance type; Epiphyseal dysplasia, multiple, with myopia and deafness; Czech dysplasia Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC) Osteoarthritis with mild chondrodysplasia
GWAS		Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Blood protein levels ( 29875488)	Lymphocyte counts ( 32888494) Macular thickness ( 30535121) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Retinal detachment or retinal break ( 31816047) Rheumatoid arthritis ( 30891314)
Interacting Genes		6 interacting genes: COL1A1 COL2A1 FBLN2 FN1 HSPG2 NID1	33 interacting genes: ANXA5 BGN BMP2 C1QA CHAD COL6A1 COL9A2 COL9A3 COMP DDR1 FGF7 FN1 HTRA1 HYAL1 ITGA2B KEAP1 LOXL4 MAG MATN1 MMP1 MMP13 PCOLCE PDGFA PDGFB PDIA2 PKD1 PRELP RELA SPARC TGFB1 TGFBI THBS1 TNFRSF10A
Entrez ID		5549	1280
HPRD ID		03556	00361
Ensembl ID		ENSG00000188783	ENSG00000139219
Uniprot IDs		P51888	P02458
PDB IDs			1U5M 2FSE 2SEB 5NIR 5OCX 5OCY 6BIN 6NIX
Enriched GO Terms of Interacting Partners?
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