FANCI and WDR48

Data Source:
BioGRID (pull down)

		FANCI	WDR48
Description		FA complementation group I	WD repeat domain 48
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane	Nucleus Nucleoplasm Lysosome Late Endosome Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Protein Binding DNA Polymerase Binding	DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding Ubiquitin Binding
	Biological Process	Cell Cycle Positive Regulation Of Protein Ubiquitination Interstrand Cross-link Repair	Double-strand Break Repair Via Homologous Recombination Cellular Response To DNA Damage Stimulus Spermatogenesis Single Fertilization Viral Process Protein Deubiquitination Multicellular Organism Growth Interstrand Cross-link Repair DNA Damage Response, Detection Of DNA Damage Skin Development Embryonic Organ Development Skeletal System Morphogenesis Homeostasis Of Number Of Cells Positive Regulation Of Epithelial Cell Proliferation Seminiferous Tubule Development Regulation Of Protein Monoubiquitination Positive Regulation Of Protein Deubiquitination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes	Recognition of DNA damage by PCNA-containing replication complex Ub-specific processing proteases Fanconi Anemia Pathway Signaling by cytosolic PDGFRA and PDGFRB fusion proteins
Drugs
Diseases		Fanconi anemia
GWAS		Height ( 25282103) Menopause (age at onset) ( 26414677) Red cell distribution width ( 32888494) Serum immune biomarker levels ( 32066700)	Metabolic syndrome ( 31589552) Social communication problems ( 24564958)
Interacting Genes		13 interacting genes: AKT1 APP ATR BRCA2 FANCD2 FANCL MTDH MTNR1B PIAS1 RAD51 UBL5 USP1 WDR48	7 interacting genes: FANCI NMRAL1 PAXIP1 PCNA PHLPP1 RAD51 UBC
Entrez ID		55215	57599
HPRD ID		13339	11146
Ensembl ID		ENSG00000140525	ENSG00000114742
Uniprot IDs		B3KNW8 Q9NVI1	A0A024R2L1 Q8TAF3
PDB IDs		6VAA 6VAD 6VAE 6VAF	5CVL 5CVN 5CVO 5K1A 5K1B 5K1C 5L8E 5L8W 6JLQ
Enriched GO Terms of Interacting Partners?
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