APPL2 and RAB22A

Data Source:
HPRD (two hybrid)

		APPL2	RAB22A
Description		adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2	RAB22A, member RAS oncogene family
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Endosome Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Vesicle Early Phagosome Ruffle Membrane Early Phagosome Membrane Macropinosome Extracellular Exosome	Ruffle Early Endosome Late Endosome Plasma Membrane Endosome Membrane Endomembrane System Actin Cytoskeleton Phagocytic Vesicle Membrane Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Diet Induced Thermogenesis Protein Import Into Nucleus Cell Cycle Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cold Acclimation Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Glucose Homeostasis Regulation Of Innate Immune Response Negative Regulation Of Fatty Acid Oxidation Negative Regulation Of Glucose Import Negative Regulation Of Neurogenesis Protein Homotetramerization Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Macropinocytosis Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Neural Precursor Cell Proliferation	Intracellular Protein Transport Endocytosis Endosome Organization Regulation Of Vesicle Size
Pathways			RAB geranylgeranylation
Drugs
Diseases
GWAS		Mosquito bite size ( 28199695)	Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429) Metabolite levels ( 23823483) Nickel levels ( 26025379)
Interacting Genes		29 interacting genes: APPL1 ATF3 CNMD CRADD CRBN CRLF3 DOK3 EPM2AIP1 KIFC3 KMT2C LDHAL6B LGALS9C LINC02875 LIX1 MLST8 MTA2 PINK1 POT1 PRR35 RAB22A RAB5A RAB5C RAI2 RBBP7 RBP7 RUVBL2 SUV39H2 TINF2 TSC1	7 interacting genes: ALS2CL APPL2 EEA1 RAB3GAP1 RAB7A RABAC1 SMURF2
Entrez ID		55198	57403
HPRD ID		06945	06696
Ensembl ID		ENSG00000136044	ENSG00000124209
Uniprot IDs		Q8NEU8	Q9UL26
PDB IDs		4H8S 5C5B
Enriched GO Terms of Interacting Partners?
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