APPL2 and APPL1

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		APPL2	APPL1
Description		adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
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GO Annotations	Cellular Component	Ruffle Nucleus Endosome Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Vesicle Early Phagosome Ruffle Membrane Early Phagosome Membrane Macropinosome Extracellular Exosome	Ruffle Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Vesicle Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Macropinosome Extracellular Exosome Intracellular Vesicle
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein Kinase B Binding Protein-containing Complex Binding Beta-tubulin Binding
	Biological Process	Diet Induced Thermogenesis Protein Import Into Nucleus Cell Cycle Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cold Acclimation Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Glucose Homeostasis Regulation Of Innate Immune Response Negative Regulation Of Fatty Acid Oxidation Negative Regulation Of Glucose Import Negative Regulation Of Neurogenesis Protein Homotetramerization Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Macropinocytosis Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Neural Precursor Cell Proliferation	Protein Import Into Nucleus Cell Cycle Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Innate Immune Response Regulation Of Glucose Import Positive Regulation Of Glucose Import Positive Regulation Of Melanin Biosynthetic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macropinocytosis Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Caspase activation via Dependence Receptors in the absence of ligand
Drugs
Diseases
GWAS		Mosquito bite size ( 28199695)
Interacting Genes		29 interacting genes: APPL1 ATF3 CNMD CRADD CRBN CRLF3 DOK3 EPM2AIP1 KIFC3 KMT2C LDHAL6B LGALS9C LINC02875 LIX1 MLST8 MTA2 PINK1 POT1 PRR35 RAB22A RAB5A RAB5C RAI2 RBBP7 RBP7 RUVBL2 SUV39H2 TINF2 TSC1	64 interacting genes: ADI1 ADIPOR1 ADIPOR2 AGL AKT1 AKT2 ANKRD1 APPL2 ATP2A1 BATF3 BIN1 BRWD1 C1QTNF9 CBL CBLB CIPC CMTM4 CTTNBP2 DACT1 DCC DNM2 DOK2 DOK3 DOK7 DPYSL5 DTNA DYSF EGFR FARS2 FSHR GPC3 HDAC2 HSPB1 ID1 INO80E KLF15 KXD1 LUC7L MAGEA9 MAGEC3 MAP3K1 MEOX1 MTA2 MYCBP2 MYH3 PIK3CA PIK3R1 PIK3R2 PLEKHF2 PNMA5 RAB21 RAB5A RBBP7 RHEBL1 RUVBL2 SCAPER SH2D2A SOCS6 SPART TP53 TP53BP2 TRAF2 UBE2O ZNF829
Entrez ID		55198	26060
HPRD ID		06945	05053
Ensembl ID		ENSG00000136044	ENSG00000157500
Uniprot IDs		Q8NEU8	Q9UKG1
PDB IDs		4H8S 5C5B	2EJ8 2ELA 2ELB 2Q12 2Q13 2Z0N 2Z0O 5C5B
Enriched GO Terms of Interacting Partners?
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