CDCA8 and SENP3

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		CDCA8	SENP3
Description		cell division cycle associated 8	SUMO specific peptidase 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Nucleoplasm Nucleolus Cytosol Chromocenter Midbody Chromosome Passenger Complex Protein-containing Complex Intercellular Bridge Spindle Midzone	Nucleus Nucleoplasm Nucleolus Cytoplasm MLL1 Complex
	Molecular Function	Protein Binding	Protein Binding Cysteine-type Peptidase Activity SUMO-specific Protease Activity
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Metaphase Plate Congression Chromosome Organization Cell Division	RRNA Processing Protein Desumoylation
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Axial length ( 24144296) Eyebrow thickness ( 26926045)	Brain morphology (MOSTest) ( 32665545) IgM levels ( 23118916) Refractive error ( 32231278)
Interacting Genes		26 interacting genes: AURKB BIRC5 EMILIN1 FBXO17 GYS1 H3C14 HLA-DRB3 HMBOX1 INCENP MAPKAPK5 NEK3 NKAPD1 NTAQ1 PIAS2 PIH1D2 RANBP2 RPRD1B SENP3 SET SGO1 SGO2 SNAPC5 SPANXN2 TTK UBE2I ZNF277	18 interacting genes: ADRB2 ATF7IP BECN1 CDCA8 CDK4 CDK6 CEP19 DNM1L EP300 HIC1 MDM2 NPM1 PARP1 SUMO2 TRIM54 TRIM63 USP15 USP21
Entrez ID		55143	26168
HPRD ID		13017	08339
Ensembl ID		ENSG00000134690	ENSG00000161956
Uniprot IDs		Q53HL2	Q9H4L4
PDB IDs		2KDD 2QFA 2RAW 2RAX 6YIE 6YIF 6YIH
Enriched GO Terms of Interacting Partners?
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