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FBXO34 and SKP1
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(two hybrid)
FBXO34
SKP1
Description
F-box protein 34
S-phase kinase associated protein 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
SCF Ubiquitin Ligase Complex
Cul7-RING Ubiquitin Ligase Complex
PcG Protein Complex
Molecular Function
Protein Binding
Protein Binding
Beta-catenin Binding
Protein Domain Specific Binding
Cullin Family Protein Binding
F-box Domain Binding
Ubiquitin Ligase-substrate Adaptor Activity
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Cellular Iron Ion Homeostasis
SCF Complex Assembly
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Wnt Signaling Pathway
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Histone H2A Monoubiquitination
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Stress-activated MAPK Cascade
Maintenance Of Protein Location In Nucleus
Interleukin-1-mediated Signaling Pathway
Protein K48-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
Vpu mediated degradation of CD4
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
NOTCH1 Intracellular Domain Regulates Transcription
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Circadian Clock
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
1-naphthaleneacetic acid
(2S)-2-(1H-indol-3-yl)hexanoic acid
(2S)-2-(1H-indol-3-yl)pentanoic acid
(2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid
Indoleacetic acid
Diseases
GWAS
Blood protein levels (
28240269
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Immature fraction of reticulocytes (
32888494
)
Mean platelet volume (
32888494
)
Testicular germ cell tumor (
28604728
)
Urate levels (
31578528
)
White blood cell count (
32888494
)
Mean platelet volume (
32888494
)
Systemic lupus erythematosus (
27399966
26502338
)
Interacting Genes
24 interacting genes:
ALPP
COL8A1
DISC1
FGF14
KRT40
KRTAP10-1
KRTAP10-11
KRTAP10-5
KRTAP10-8
KRTAP12-4
KRTAP4-11
KRTAP4-12
KRTAP4-5
KRTAP5-3
KRTAP9-2
KRTAP9-3
KRTAP9-8
MDFI
MTUS2
OIT3
SKP1
SMAD4
TGFBR1
VWC2L
80 interacting genes:
ANKRD36BP1
APIP
BTRC
CACYBP
CAND1
CCNA2
CDCA3
CDK2
CDK4
CDK9
CDKN1A
CDKN1B
CENPE
CUL1
CUL7
DDX19B
FBH1
FBXL14
FBXL2
FBXL20
FBXL22
FBXL3
FBXL4
FBXL5
FBXL6
FBXL8
FBXO11
FBXO15
FBXO16
FBXO17
FBXO2
FBXO25
FBXO27
FBXO28
FBXO3
FBXO32
FBXO34
FBXO4
FBXO43
FBXO44
FBXO46
FBXO48
FBXO5
FBXO6
FBXO7
FBXO8
FBXO9
FBXW2
FBXW5
FBXW7
FBXW8
GHR
GLMN
GPS1
HSP90AA1
KCTD9
LAMTOR5
LMO2
MED21
MEOX2
MTUS1
MYC
NFKBIA
NFKBIB
NFKBIE
NUDT9P1
PPARGC1A
PPP1CA
PTEN
RBX1
SEC23B
SKP2
SUGT1
TBL1X
TERF1
TRRAP
TTC21A
TTC9C
UBE2D1
UHRF2
Entrez ID
55030
6500
HPRD ID
16442
03255
Ensembl ID
ENSG00000178974
ENSG00000113558
Uniprot IDs
A0A024R653
Q9NWN3
P63208
PDB IDs
1FQV
1FS1
1FS2
1LDK
1P22
2ASS
2AST
2E31
2E32
2OVP
2OVQ
2OVR
3L2O
3WSO
4I6J
5IBK
5JH5
5K35
5V4B
5VZT
5VZU
5XYL
6BVA
6BYH
6C16
6M90
6M91
6M92
6M93
6M94
6O60
6TTU
6VCD
6W66
6WCQ
6WNX
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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