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SKP1 and CUL1
Data Source:
HPRD
(in vitro, in vivo)
SKP1
CUL1
Description
S-phase kinase associated protein 1
cullin 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
SCF Ubiquitin Ligase Complex
Cul7-RING Ubiquitin Ligase Complex
PcG Protein Complex
Nucleoplasm
Cytosol
Plasma Membrane
SCF Ubiquitin Ligase Complex
Cullin-RING Ubiquitin Ligase Complex
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Molecular Function
Protein Binding
Beta-catenin Binding
Protein Domain Specific Binding
Cullin Family Protein Binding
F-box Domain Binding
Ubiquitin Ligase-substrate Adaptor Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Cellular Iron Ion Homeostasis
SCF Complex Assembly
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Wnt Signaling Pathway
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Histone H2A Monoubiquitination
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Stress-activated MAPK Cascade
Maintenance Of Protein Location In Nucleus
Interleukin-1-mediated Signaling Pathway
Protein K48-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Protein Monoubiquitination
Cellular Iron Ion Homeostasis
Cell Population Proliferation
Animal Organ Morphogenesis
SCF Complex Assembly
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Wnt Signaling Pathway
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Stress-activated MAPK Cascade
Interleukin-1-mediated Signaling Pathway
Protein K48-linked Ubiquitination
Intrinsic Apoptotic Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Pathways
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
Vpu mediated degradation of CD4
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
NOTCH1 Intracellular Domain Regulates Transcription
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Circadian Clock
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
NOTCH1 Intracellular Domain Regulates Transcription
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Circadian Clock
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
1-naphthaleneacetic acid
(2S)-2-(1H-indol-3-yl)hexanoic acid
(2S)-2-(1H-indol-3-yl)pentanoic acid
(2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid
Indoleacetic acid
Diseases
GWAS
Mean platelet volume (
32888494
)
Systemic lupus erythematosus (
27399966
26502338
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Uterine fibroid size (maximum volume) (
30196971
)
Interacting Genes
80 interacting genes:
ANKRD36BP1
APIP
BTRC
CACYBP
CAND1
CCNA2
CDCA3
CDK2
CDK4
CDK9
CDKN1A
CDKN1B
CENPE
CUL1
CUL7
DDX19B
FBH1
FBXL14
FBXL2
FBXL20
FBXL22
FBXL3
FBXL4
FBXL5
FBXL6
FBXL8
FBXO11
FBXO15
FBXO16
FBXO17
FBXO2
FBXO25
FBXO27
FBXO28
FBXO3
FBXO32
FBXO34
FBXO4
FBXO43
FBXO44
FBXO46
FBXO48
FBXO5
FBXO6
FBXO7
FBXO8
FBXO9
FBXW2
FBXW5
FBXW7
FBXW8
GHR
GLMN
GPS1
HSP90AA1
KCTD9
LAMTOR5
LMO2
MED21
MEOX2
MTUS1
MYC
NFKBIA
NFKBIB
NFKBIE
NUDT9P1
PPARGC1A
PPP1CA
PTEN
RBX1
SEC23B
SKP2
SUGT1
TBL1X
TERF1
TRRAP
TTC21A
TTC9C
UBE2D1
UHRF2
56 interacting genes:
BTRC
CAND1
CDC34
CDCA3
CDK9
CDKN1B
CENPE
CENPW
CHEK1
CHUK
CKS1B
COMMD1
COPS5
COPS6
COPS8
DLEU2
E2F1
FBH1
FBXO25
FBXW11
FBXW2
FBXW4
FBXW7
GHR
GPS1
HIPK2
KHNYN
NEDD8
NFKBIA
NFKBIB
NFKBIE
NLK
NLRP3
NR1D2
PPP1CA
PRKN
PRPF40A
PSMB4
PSMD4
PTTG1
RAC2
RANBP2
RBX1
RICTOR
RNF7
SENP8
SKP1
SKP2
SMAD3
THRA
TRIM21
UBC
UBE2E3
UBE2F
UBE2M
ZC3HC1
Entrez ID
6500
8454
HPRD ID
03255
04389
Ensembl ID
ENSG00000113558
ENSG00000055130
Uniprot IDs
P63208
A0A090N7U0
B3KTW0
Q13616
PDB IDs
1FQV
1FS1
1FS2
1LDK
1P22
2ASS
2AST
2E31
2E32
2OVP
2OVQ
2OVR
3L2O
3WSO
4I6J
5IBK
5JH5
5K35
5V4B
5VZT
5VZU
5XYL
6BVA
6BYH
6C16
6M90
6M91
6M92
6M93
6M94
6O60
6TTU
6VCD
6W66
6WCQ
6WNX
1LDJ
1LDK
1U6G
3RTR
3TDU
3TDZ
4F52
4P5O
5V89
6TTU
6WCQ
Enriched GO Terms of Interacting Partners
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