APTX and PNMA3

Data Source:
BioGRID (two hybrid)

		APTX	PNMA3
Description		aprataxin	PNMA family member 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm	Nucleolus
	Molecular Function	Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Double-stranded RNA Binding Protein Binding Phosphoglycolate Phosphatase Activity Mismatched DNA Binding DNA 5'-adenosine Monophosphate Hydrolase Activity Metal Ion Binding Protein N-terminus Binding Phosphoprotein Binding Single-strand Break-containing DNA Binding	Nucleic Acid Binding Protein Binding Zinc Ion Binding
	Biological Process	Single Strand Break Repair DNA Ligation Double-strand Break Repair Cellular Response To DNA Damage Stimulus Dephosphorylation Regulation Of Protein Stability Response To Hydrogen Peroxide Nucleic Acid Phosphodiester Bond Hydrolysis	Positive Regulation Of Apoptotic Process
Pathways
Drugs
Diseases		Coenzyme Q10 deficiency Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2)
GWAS		Height ( 28552196) Menopause (age at onset) ( 26414677)
Interacting Genes		18 interacting genes: CALCOCO1 CEP350 CNTROB FLAD1 HIVEP1 MAPKBP1 MBP PARP1 PICK1 PNMA1 PNMA3 SYT17 TP53 TRIM37 TSPYL2 XRCC1 XRCC4 ZNF639	12 interacting genes: APTX C19orf25 CCDC187 CNNM3 LNX1 PRPF31 RPH3AL SLC25A37 SMG9 TIGD3 UBQLN2 ZBTB47
Entrez ID		54840	29944
HPRD ID		05892	06677
Ensembl ID		ENSG00000137074	ENSG00000183837
Uniprot IDs		Q7Z2E3	Q9UL41
PDB IDs		3KT9 4NDF 4NDG 4NDH 4NDI 6CVO 6CVP 6CVQ 6CVR 6CVS 6CVT
Enriched GO Terms of Interacting Partners?
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