PNMA3 and APTX

Data Source:
BioGRID (two hybrid)

		PNMA3	APTX
Description		PNMA family member 3	aprataxin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Nucleic Acid Binding Protein Binding Zinc Ion Binding	Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Double-stranded RNA Binding Protein Binding Phosphoglycolate Phosphatase Activity Mismatched DNA Binding DNA 5'-adenosine Monophosphate Hydrolase Activity Metal Ion Binding Protein N-terminus Binding Phosphoprotein Binding Single-strand Break-containing DNA Binding
	Biological Process	Positive Regulation Of Apoptotic Process	Single Strand Break Repair DNA Ligation Double-strand Break Repair Cellular Response To DNA Damage Stimulus Dephosphorylation Regulation Of Protein Stability Response To Hydrogen Peroxide Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways
Drugs
Diseases			Coenzyme Q10 deficiency Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2)
GWAS			Height ( 28552196) Menopause (age at onset) ( 26414677)
Interacting Genes		12 interacting genes: APTX C19orf25 CCDC187 CNNM3 LNX1 PRPF31 RPH3AL SLC25A37 SMG9 TIGD3 UBQLN2 ZBTB47	18 interacting genes: CALCOCO1 CEP350 CNTROB FLAD1 HIVEP1 MAPKBP1 MBP PARP1 PICK1 PNMA1 PNMA3 SYT17 TP53 TRIM37 TSPYL2 XRCC1 XRCC4 ZNF639
Entrez ID		29944	54840
HPRD ID		06677	05892
Ensembl ID		ENSG00000183837	ENSG00000137074
Uniprot IDs		Q9UL41	Q7Z2E3
PDB IDs			3KT9 4NDF 4NDG 4NDH 4NDI 6CVO 6CVP 6CVQ 6CVR 6CVS 6CVT
Enriched GO Terms of Interacting Partners?
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