RNF111 and DTX3L

Data Source:
BioGRID (two hybrid)

		RNF111	DTX3L
Description		ring finger protein 111	deltex E3 ubiquitin ligase 3L
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Early Endosome Cytosol Early Endosome Membrane Protein-containing Complex
	Molecular Function	Protein Binding SUMO Polymer Binding SMAD Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Enzyme Inhibitor Activity Protein Binding Enzyme Activator Activity Enzyme Binding Histone Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity STAT Family Protein Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Pattern Specification Process Protein Ubiquitination Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Global Genome Nucleotide-excision Repair	Protein Polyubiquitination Positive Regulation Of Defense Response To Virus By Host Double-strand Break Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Notch Signaling Pathway Endosome To Lysosome Transport Histone Monoubiquitination Protein Transport Viral Process Protein Ubiquitination Positive Regulation Of Protein Binding Histone H2A Ubiquitination Histone H2B Ubiquitination Positive Regulation Of Chromatin Binding Innate Immune Response Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Ubiquitin-protein Transferase Activity Defense Response To Virus Protein Autoubiquitination Protein K48-linked Ubiquitination Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Receptor Catabolic Process Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Formation of Incision Complex in GG-NER Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Asperger disorder ( 21182207) Atopic dermatitis ( 25865352) Cerebrospinal fluid AB1-42 levels ( 28247064) Metabolite levels ( 22916037) Social communication problems ( 24047820)	Low density lipoprotein cholesterol levels ( 32154731) Major depressive disorder ( 22472876)
Interacting Genes		54 interacting genes: ACTN3 ANAPC11 AP2M1 AXIN1 CREB1 CREBBP CSNK2A1 CTBP1 DTX3L EDARADD KRTAP1-1 KRTAP5-9 LCE4A LRSAM1 MARCHF7 MDFI MVP NBPF19 NOTCH2NLA PAX6 PHF7 PML PSME3 PTPN3 SDCBP2 SMAD3 SMAD6 SMAD7 SMURF2 SUMO1 SUMO2 SUMO3 TRAF5 TRIM21 TRIM8 TSG101 TSPYL1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2M UBE2N UBE2Q2 UBE2V1 UBE2W VAPB	20 interacting genes: DTX1 H2AZ2 ITCH PARP9 PHF7 RNF111 SPG21 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2R2 UBE2W
Entrez ID		54778	151636
HPRD ID		09318	16843
Ensembl ID		ENSG00000157450	ENSG00000163840
Uniprot IDs		A0A024R5T5 Q6ZNA4	Q8TDB6
PDB IDs		2KIZ 5LG0 5LG7	3PG6
Enriched GO Terms of Interacting Partners?
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