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PPARA and PRKCD
Data Source:
HPRD
(in vitro)
PPARA
PRKCD
Description
peroxisome proliferator activated receptor alpha
protein kinase C delta
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Cell-cell Junction
Nuclear Matrix
Azurophil Granule Lumen
Endolysosome
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Repressing Transcription Factor Binding
Transcription Coactivator Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Steroid Hormone Receptor Activity
Nuclear Receptor Activity
Protein Binding
Transcription Factor Binding
Drug Binding
Zinc Ion Binding
Lipid Binding
Phosphatase Binding
Protein Domain Specific Binding
Ubiquitin Conjugating Enzyme Binding
Sequence-specific DNA Binding
Protein-containing Complex Binding
NFAT Protein Binding
MDM2/MDM4 Family Protein Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Kinase C Activity
Calcium-dependent Protein Kinase C Activity
Calcium-independent Protein Kinase C Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Enzyme Activator Activity
Enzyme Binding
Kinase Binding
Protein Kinase Binding
Insulin Receptor Substrate Binding
Metal Ion Binding
Protein Serine Kinase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Response To Hypoxia
Transcription Initiation From RNA Polymerase II Promoter
Fatty Acid Metabolic Process
Heart Development
Epidermis Development
Cellular Response To Starvation
Hormone-mediated Signaling Pathway
Regulation Of Cellular Ketone Metabolic Process
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Lipid Localization
Negative Regulation Of Cholesterol Storage
Negative Regulation Of Sequestering Of Triglyceride
Regulation Of Lipid Metabolic Process
Regulation Of Fatty Acid Metabolic Process
Cell Differentiation
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Intracellular Receptor Signaling Pathway
Positive Regulation Of Fatty Acid Beta-oxidation
Negative Regulation Of Protein Binding
Negative Regulation Of Appetite
Response To Insulin
Circadian Regulation Of Gene Expression
Response To Lipid
Behavioral Response To Nicotine
Wound Healing
Lipoprotein Metabolic Process
Regulation Of Circadian Rhythm
Steroid Hormone Mediated Signaling Pathway
Positive Regulation Of Viral Genome Replication
Response To Ethanol
Positive Regulation Of Gluconeogenesis
Negative Regulation Of Blood Pressure
Negative Regulation Of Glycolytic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Fatty Acid Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fatty Acid Oxidation
Positive Regulation Of Lipid Biosynthetic Process
Negative Regulation Of Inflammatory Response
Negative Regulation Of Protein Kinase B Signaling
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Enamel Mineralization
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of Neuron Death
Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Negative Regulation Of Leukocyte Cell-cell Adhesion
Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Negative Regulation Of Hepatocyte Apoptotic Process
Regulation Of Fatty Acid Transport
Negative Regulation Of Signaling Receptor Activity
Positive Regulation Of ATP Biosynthetic Process
Stimulatory C-type Lectin Receptor Signaling Pathway
Protein Phosphorylation
Apoptotic Process
Cell Cycle
Signal Transduction
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Regulation Of Signaling Receptor Activity
Immunoglobulin Mediated Immune Response
Histone Phosphorylation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Termination Of Signal Transduction
Platelet Activation
Negative Regulation Of Actin Filament Polymerization
Positive Regulation Of Endodeoxyribonuclease Activity
Negative Regulation Of Protein Binding
Activation Of Protein Kinase Activity
Positive Regulation Of Superoxide Anion Generation
Regulation Of Actin Cytoskeleton Organization
Negative Regulation Of Glial Cell Apoptotic Process
Cellular Response To UV
Positive Regulation Of Protein Dephosphorylation
Intracellular Signal Transduction
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
B Cell Proliferation
Neutrophil Activation
Positive Regulation Of Protein Import Into Nucleus
Defense Response To Bacterium
Neutrophil Degranulation
Negative Regulation Of MAP Kinase Activity
Regulation Of MRNA Stability
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
Protein Stabilization
Negative Regulation Of Filopodium Assembly
Cell Chemotaxis
Interferon-gamma-mediated Signaling Pathway
Cellular Response To Hydrogen Peroxide
Cellular Response To Hydroperoxide
Negative Regulation Of Platelet Aggregation
Cellular Senescence
Positive Regulation Of Phospholipid Scramblase Activity
Cellular Response To Angiotensin
Regulation Of Ceramide Biosynthetic Process
Positive Regulation Of Ceramide Biosynthetic Process
Positive Regulation Of Glucosylceramide Catabolic Process
Positive Regulation Of Sphingomyelin Catabolic Process
Positive Regulation Of Response To DNA Damage Stimulus
Positive Regulation Of Apoptotic Signaling Pathway
Pathways
RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
PPARA activates gene expression
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by PPARalpha
Circadian Clock
SUMOylation of intracellular receptors
Apoptotic cleavage of cellular proteins
Calmodulin induced events
Effects of PIP2 hydrolysis
SHC1 events in ERBB2 signaling
DAG and IP3 signaling
Role of phospholipids in phagocytosis
G alpha (z) signalling events
HuR (ELAVL1) binds and stabilizes mRNA
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
RHO GTPases Activate NADPH Oxidases
Neutrophil degranulation
Interferon gamma signaling
Drugs
alpha-Linolenic acid
Icosapent
Troglitazone
Valproic acid
Indomethacin
Rosiglitazone
Fenoprofen
Clofibrate
Fenofibrate
Ibuprofen
Amiodarone
Gemfibrozil
Bezafibrate
Prasterone
N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide
Flufenamic acid
Resveratrol
Phthalic Acid
Lauric acid
Stearic acid
Doconexent
Palmitic Acid
Oleic Acid
Caprylic acid
Arachidonic Acid
Reglitazar
Elafibranor
Cardarine
Muraglitazar
Ertiprotafib
Ragaglitazar
Tesaglitazar
GW-590735
Indeglitazar
Myristic acid
Aleglitazar
Clinofibrate
Ciprofibrate
Dexibuprofen
Soybean oil
Omega-3 fatty acids
Myrrh
Isoflavone
Leukotriene B4
Fenofibric acid
Fish oil
Tamoxifen
13-Acetylphorbol
Ingenol mebutate
Fostamatinib
Diseases
GWAS
Cholesterol, total (
24097068
)
CTACK levels (
27989323
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Impulsivity (motor) (
30718321
)
LDL cholesterol (
24097068
)
Refractive error (
32231278
)
Resting-state electroencephalogram vigilance (
29703947
)
Triglyceride levels (
32203549
)
Type 2 diabetes (
31049640
)
Very long-chain saturated fatty acid levels (fatty acid 20:0) (
25378659
)
Bipolar disorder (
21926972
)
Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) (
30120083
)
Ulcerative colitis (
23128233
)
Waist circumference adjusted for body mass index (
28552196
)
Interacting Genes
70 interacting genes:
AIP
AKAP13
ANKRD11
AQP1
BCL2
CCDC179
CDC34
CDK3
CEP350
CHD9
CHIC2
COL8A1
CTNNA3
DAP3
DUT
EP300
EXOSC4
FABP1
FAM90A1
FAM9B
FBLN1
FOXA3
GADD45A
GADD45B
GADD45G
GPANK1
HELZ2
HOXC8
HSP90AA1
KCTD7
KRTAP10-1
LAMTOR5
MAPK1
MAPK3
MECR
MED1
MED24
NCOA1
NCOA2
NCOA3
NCOR1
NCOR2
NR1H2
NR1H3
NRBF2
NRIP1
PAQR3
PICK1
PIK3R3
POU1F1
PPARGC1A
PPARGC1B
PRKCA
PRKCD
PRMT1
PRMT8
RELA
RXRA
RXRG
SDCBP
SIRT1
STAC3
TNP1
TRIM55
TRIM63
UBE2I
VWA5A
VWC2L
ZNF587
ZSCAN23
120 interacting genes:
ACTA1
ACTA2
ACTB
ADAM9
ADCY7
ADD1
ADD2
ADRA2A
ADRB2
AFAP1
AKT3
APP
ART3
BDKRB2
C1QBP
CD34
CDCP1
CHAT
CNP
CREBBP
CYTH1
DAB2
DYNC1H1
EEF1A1
EGFR
EIF2S1
ELAVL1
EP300
ESRRA
FLI1
FSCN1
FYN
GABRA1
GAP43
GNA12
GNA13
GNAZ
GRK2
GRM5
GSK3A
H1-1
H1-5
HABP4
HDAC5
HNRNPK
HSP90AA1
HSPA4
IGF1R
IKBKB
IL6ST
INSR
IRS1
ITGA6
ITGB2
ITGB4
ITGB7
ITPR1
KCNJ1
KCNJ4
KLF5
LCK
LMNB1
LMNB2
LYN
MACF1
MAPK1
MAPK3
MAPT
MBP
MEP1B
MS4A2
MUC1
NCF1
NCF4
NFE2L2
NOTCH1
NUMB
OPRD1
PAK1
PDP1
PDP2
PDPK1
PEBP1
PIK3CA
PIK3CB
PLCB1
PLD2
PLSCR1
PLSCR3
PPARA
PPM1A
PPP1CA
PPP2CA
PPP2R5C
PRKCZ
PRKDC
PTK2B
PTPN22
PTPN6
PTPRA
RAC1
RACK1
RAF1
RASGRP3
RIPK4
RUNX2
SDC4
SHC1
SPRY2
SQSTM1
SRC
STAT1
STAT3
TAGLN
TIAM1
TNFRSF1A
VCP
YWHAB
YWHAG
YWHAZ
Entrez ID
5465
5580
HPRD ID
01369
01501
Ensembl ID
ENSG00000186951
ENSG00000163932
Uniprot IDs
F1D8S4
Q07869
A0A024R328
B4DFV1
Q05655
PDB IDs
1I7G
1K7L
1KKQ
2NPA
2P54
2REW
2ZNN
3ET1
3FEI
3G8I
3KDT
3KDU
3SP6
3VI8
4BCR
4CI4
5AZT
5HYK
6KXX
6KXY
6L96
1YRK
2YUU
Enriched GO Terms of Interacting Partners
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