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PPARA and COL8A1
Data Source:
BioGRID
(two hybrid)
PPARA
COL8A1
Description
peroxisome proliferator activated receptor alpha
collagen type VIII alpha 1 chain
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Extracellular Region
Collagen Type VIII Trimer
Extracellular Space
Endoplasmic Reticulum Lumen
Extracellular Matrix
Collagen-containing Extracellular Matrix
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Repressing Transcription Factor Binding
Transcription Coactivator Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Steroid Hormone Receptor Activity
Nuclear Receptor Activity
Protein Binding
Transcription Factor Binding
Drug Binding
Zinc Ion Binding
Lipid Binding
Phosphatase Binding
Protein Domain Specific Binding
Ubiquitin Conjugating Enzyme Binding
Sequence-specific DNA Binding
Protein-containing Complex Binding
NFAT Protein Binding
MDM2/MDM4 Family Protein Binding
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Response To Hypoxia
Transcription Initiation From RNA Polymerase II Promoter
Fatty Acid Metabolic Process
Heart Development
Epidermis Development
Cellular Response To Starvation
Hormone-mediated Signaling Pathway
Regulation Of Cellular Ketone Metabolic Process
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Lipid Localization
Negative Regulation Of Cholesterol Storage
Negative Regulation Of Sequestering Of Triglyceride
Regulation Of Lipid Metabolic Process
Regulation Of Fatty Acid Metabolic Process
Cell Differentiation
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Intracellular Receptor Signaling Pathway
Positive Regulation Of Fatty Acid Beta-oxidation
Negative Regulation Of Protein Binding
Negative Regulation Of Appetite
Response To Insulin
Circadian Regulation Of Gene Expression
Response To Lipid
Behavioral Response To Nicotine
Wound Healing
Lipoprotein Metabolic Process
Regulation Of Circadian Rhythm
Steroid Hormone Mediated Signaling Pathway
Positive Regulation Of Viral Genome Replication
Response To Ethanol
Positive Regulation Of Gluconeogenesis
Negative Regulation Of Blood Pressure
Negative Regulation Of Glycolytic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Fatty Acid Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fatty Acid Oxidation
Positive Regulation Of Lipid Biosynthetic Process
Negative Regulation Of Inflammatory Response
Negative Regulation Of Protein Kinase B Signaling
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Enamel Mineralization
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of Neuron Death
Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Negative Regulation Of Leukocyte Cell-cell Adhesion
Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Negative Regulation Of Hepatocyte Apoptotic Process
Regulation Of Fatty Acid Transport
Negative Regulation Of Signaling Receptor Activity
Positive Regulation Of ATP Biosynthetic Process
Angiogenesis
Cell Adhesion
Positive Regulation Of Cell-substrate Adhesion
Extracellular Matrix Organization
Endodermal Cell Differentiation
Camera-type Eye Morphogenesis
Epithelial Cell Proliferation
Pathways
RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
PPARA activates gene expression
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by PPARalpha
Circadian Clock
SUMOylation of intracellular receptors
Collagen degradation
Collagen degradation
Collagen biosynthesis and modifying enzymes
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Collagen chain trimerization
Drugs
alpha-Linolenic acid
Icosapent
Troglitazone
Valproic acid
Indomethacin
Rosiglitazone
Fenoprofen
Clofibrate
Fenofibrate
Ibuprofen
Amiodarone
Gemfibrozil
Bezafibrate
Prasterone
N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide
Flufenamic acid
Resveratrol
Phthalic Acid
Lauric acid
Stearic acid
Doconexent
Palmitic Acid
Oleic Acid
Caprylic acid
Arachidonic Acid
Reglitazar
Elafibranor
Cardarine
Muraglitazar
Ertiprotafib
Ragaglitazar
Tesaglitazar
GW-590735
Indeglitazar
Myristic acid
Aleglitazar
Clinofibrate
Ciprofibrate
Dexibuprofen
Soybean oil
Omega-3 fatty acids
Myrrh
Isoflavone
Leukotriene B4
Fenofibric acid
Fish oil
Diseases
GWAS
Cholesterol, total (
24097068
)
CTACK levels (
27989323
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Impulsivity (motor) (
30718321
)
LDL cholesterol (
24097068
)
Refractive error (
32231278
)
Resting-state electroencephalogram vigilance (
29703947
)
Triglyceride levels (
32203549
)
Type 2 diabetes (
31049640
)
Very long-chain saturated fatty acid levels (fatty acid 20:0) (
25378659
)
Advanced age-related macular degeneration (
26691988
)
Age-related macular degeneration (
20385826
23455636
)
Axial length (
24144296
)
Childhood ear infection (
27182965
)
Cleft lip with or without cleft palate (
28054174
)
Nonsyndromic cleft lip with cleft palate (
28232668
)
Optic cup area (
25631615
31798171
28073927
)
Optic disc area (
31798171
28073927
)
Refractive error (
32231278
)
Superior frontal gyrus grey matter volume (
25335168
)
Vertical cup-disc ratio (
31798171
25241763
28073927
)
Interacting Genes
70 interacting genes:
AIP
AKAP13
ANKRD11
AQP1
BCL2
CCDC179
CDC34
CDK3
CEP350
CHD9
CHIC2
COL8A1
CTNNA3
DAP3
DUT
EP300
EXOSC4
FABP1
FAM90A1
FAM9B
FBLN1
FOXA3
GADD45A
GADD45B
GADD45G
GPANK1
HELZ2
HOXC8
HSP90AA1
KCTD7
KRTAP10-1
LAMTOR5
MAPK1
MAPK3
MECR
MED1
MED24
NCOA1
NCOA2
NCOA3
NCOR1
NCOR2
NR1H2
NR1H3
NRBF2
NRIP1
PAQR3
PICK1
PIK3R3
POU1F1
PPARGC1A
PPARGC1B
PRKCA
PRKCD
PRMT1
PRMT8
RELA
RXRA
RXRG
SDCBP
SIRT1
STAC3
TNP1
TRIM55
TRIM63
UBE2I
VWA5A
VWC2L
ZNF587
ZSCAN23
78 interacting genes:
ADAMTSL4
ARMC5
BPIFA1
C11orf1
C19orf54
C22orf39
C9orf24
CCN3
CEP55
CIDEB
COL8A2
CREB5
CYSRT1
DPEP2NB
EFEMP2
FAM86C1P
FBLN2
FBXO34
FRS3
GLRX3
GSC2
HOXA1
INCA1
ITGA1
ITGA2
KLHL12
KLHL20
KPRP
KRT37
KRT40
KRT82
KRTAP1-3
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP12-3
KRTAP13-1
KRTAP13-3
KRTAP19-2
KRTAP19-5
KRTAP19-7
KRTAP26-1
KRTAP3-2
KRTAP4-12
KRTAP5-6
KRTAP5-7
KRTAP5-9
KRTAP6-2
KRTAP6-3
KRTAP9-2
KRTAP9-3
LIMS1
MAJIN
NADSYN1
NBPF19
NOTCH2NLA
OTX1
PLSCR3
POF1B
POU4F2
PPARA
RBPMS
REL
RGS20
RHBDD2
SLC35A2
SP4
SPATA8
SPRY4
SSC4D
TRIM35
UBQLN2
UBQLN4
VAC14
WFDC5
YPEL3
ZNF774
ZNHIT1
Entrez ID
5465
1295
HPRD ID
01369
00372
Ensembl ID
ENSG00000186951
ENSG00000144810
Uniprot IDs
F1D8S4
Q07869
P27658
PDB IDs
1I7G
1K7L
1KKQ
2NPA
2P54
2REW
2ZNN
3ET1
3FEI
3G8I
3KDT
3KDU
3SP6
3VI8
4BCR
4CI4
5AZT
5HYK
6KXX
6KXY
6L96
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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