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XRN1 and PPP2CA
Data Source:
BioGRID
(two hybrid)
XRN1
PPP2CA
Description
5'-3' exoribonuclease 1
protein phosphatase 2 catalytic subunit alpha
Image
No pdb structure
GO Annotations
Cellular Component
P-body
Nucleus
Cytosol
Plasma Membrane
Membrane
Dendrite
Neuronal Cell Body
Synapse
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Spindle Pole
Nucleus
Mitochondrion
Cytosol
Plasma Membrane
Microtubule Cytoskeleton
Membrane
Membrane Raft
Synapse
Extracellular Exosome
Molecular Function
G-quadruplex RNA Binding
RNA Binding
5'-3' Exoribonuclease Activity
Protein Binding
G-quadruplex DNA Binding
Telomerase RNA Binding
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein C-terminus Binding
Metal Ion Binding
Protein Heterodimerization Activity
Tau Protein Binding
GABA Receptor Binding
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Biological Process
Nuclear-transcribed MRNA Catabolic Process
RRNA Catabolic Process
Negative Regulation Of Translation
Negative Regulation Of Telomere Maintenance Via Telomerase
Response To Testosterone
Regulation Of MRNA Stability
Nuclear MRNA Surveillance
Histone MRNA Catabolic Process
Cellular Response To Cycloheximide
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Cellular Response To Puromycin
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Inactivation Of MAPK Activity
Regulation Of Protein Phosphorylation
Regulation Of DNA Replication
Regulation Of Transcription, DNA-templated
Protein Dephosphorylation
Ceramide Metabolic Process
Apoptotic Process
Mitotic Nuclear Envelope Reassembly
Mesoderm Development
RNA Splicing
Response To Organic Substance
Response To Lead Ion
Negative Regulation Of Epithelial To Mesenchymal Transition
Second-messenger-mediated Signaling
Regulation Of Wnt Signaling Pathway
Regulation Of Cell Adhesion
Negative Regulation Of Cell Growth
Peptidyl-threonine Dephosphorylation
Regulation Of Growth
Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein
Regulation Of Cell Differentiation
Meiotic Cell Cycle
Peptidyl-serine Dephosphorylation
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Microtubule Binding
Positive Regulation Of Microtubule Binding
Pathways
mRNA decay by 5' to 3' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Spry regulation of FGF signaling
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Integration of energy metabolism
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Initiation of Nuclear Envelope (NE) Reformation
CTLA4 inhibitory signaling
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Vitamin E
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases
GWAS
Benign childhood epilepsy with centro-temporal spikes (
32580138
)
Birth weight (
31043758
)
Heel bone mineral density (
30598549
)
Mean spheric corpuscular volume (
32888494
)
Mosquito bite size (
28199695
)
Waist-hip ratio (
28552196
)
Interacting Genes
66 interacting genes:
ADGRE5
ALDOA
ANGPTL6
AP1G2
ATP5MC2
B3GALT6
BAG6
C1GALT1
CBX5
CCT5
CENPBD1
CHD4
CTSB
CTSH
DCP1B
DNASE2
DPP7
DXO
EXOSC1
EXOSC10
EXOSC6
EXOSC8
FADS1
FBXO7
GLMP
HEATR1
HERC2P4
HNRNPA1
KATNB1
LDHA
LEPR
LGALS3BP
LINC01541
LSM4
MAN2C1
MFSD5
MIR34C
MIR429
MIR7-1
MTCH2
MTREX
NDUFA13
NDUFB10
NDUFB9
PABPC4
PLEKHG2
POLD2
PPP2CA
PRADC1
PSMB5
RBMX
RNF187
SDHB
SKIV2L
SMARCD2
SNHG1
SPATA20
SRRM2
STAM2
TMEM50A
UPF1
UPF2
UPF3B
VWA5B2
WAPL
ZFP36
96 interacting genes:
ADCY8
AKAP6
AKT1
AKT3
AMOTL2
APC
AXIN1
BCL2
BEST1
BMPR1B
BRAF
C3orf36
CAD
CAMK1
CARD11
CAV1
CCNG1
CCNG2
CDC42BPB
CDK2
CDK6
CDKN2C
CEBPA
CHEK2
CLPP
CSNK2B
CXCR2
DELEC1
DVL3
EEF2
EIF4EBP1
ETF1
FCAR
GABRB3
GAD1
GOLGA2
HTT
IGBP1
ISYNA1
JAK2
KISS1R
L3MBTL3
MAPK1
MAPK3
MAPT
MID1
MRPS26
MYC
MYH9
NME2
NOSIP
NXN
PACS1
PAK1
PIM1
PPP1CA
PPP2R1A
PPP2R1B
PPP2R2A
PPP2R3B
PPP2R5B
PPP2R5C
PPP2R5E
PRKAA1
PRKCD
PTEN
PTN
PXN
PYGM
RACGAP1
RBL2
RELA
RHO
RHOB
RORC
RPS6KB1
RRAS
SET
SGK1
SGO1
SGO2
STAT5A
STAT5B
STRN
TIAM1
TLX1
TP53
TRIM28
TRIM35
TRIP13
TSC2
UBAP2
VAC14
VDR
XRN1
YPEL3
Entrez ID
54464
5515
HPRD ID
10470
08912
Ensembl ID
ENSG00000114127
ENSG00000113575
Uniprot IDs
Q8IZH2
B3KUN1
P67775
PDB IDs
2IAE
2IE3
2IE4
2NPP
2NYL
2NYM
3C5W
3DW8
3FGA
3K7V
3K7W
3P71
4I5L
4I5N
4IYP
4LAC
5W0W
6NTS
Enriched GO Terms of Interacting Partners
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