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PPP2CA and NXN
Data Source:
HPRD
(in vitro, in vivo)
PPP2CA
NXN
Description
protein phosphatase 2 catalytic subunit alpha
nucleoredoxin
Image
No pdb structure
GO Annotations
Cellular Component
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Spindle Pole
Nucleus
Mitochondrion
Cytosol
Plasma Membrane
Microtubule Cytoskeleton
Membrane
Membrane Raft
Synapse
Extracellular Exosome
Nucleus
Cytosol
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein C-terminus Binding
Metal Ion Binding
Protein Heterodimerization Activity
Tau Protein Binding
GABA Receptor Binding
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Thioredoxin-disulfide Reductase Activity
Protein-disulfide Reductase Activity
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Inactivation Of MAPK Activity
Regulation Of Protein Phosphorylation
Regulation Of DNA Replication
Regulation Of Transcription, DNA-templated
Protein Dephosphorylation
Ceramide Metabolic Process
Apoptotic Process
Mitotic Nuclear Envelope Reassembly
Mesoderm Development
RNA Splicing
Response To Organic Substance
Response To Lead Ion
Negative Regulation Of Epithelial To Mesenchymal Transition
Second-messenger-mediated Signaling
Regulation Of Wnt Signaling Pathway
Regulation Of Cell Adhesion
Negative Regulation Of Cell Growth
Peptidyl-threonine Dephosphorylation
Regulation Of Growth
Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein
Regulation Of Cell Differentiation
Meiotic Cell Cycle
Peptidyl-serine Dephosphorylation
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Microtubule Binding
Positive Regulation Of Microtubule Binding
In Utero Embryonic Development
Wnt Signaling Pathway
Cell Differentiation
Negative Regulation Of Wnt Signaling Pathway
Negative Regulation Of Protein Ubiquitination
Circulatory System Development
Cellular Oxidant Detoxification
Pathways
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Spry regulation of FGF signaling
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Integration of energy metabolism
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Initiation of Nuclear Envelope (NE) Reformation
CTLA4 inhibitory signaling
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Vitamin E
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases
GWAS
Blood pressure (
24954895
)
Colorectal cancer (
27145994
24836286
)
Colorectal cancer or advanced adenoma (
30510241
)
Economic and political preferences (
22566634
)
Emphysema annual change measurement in smokers (adjusted lung density) (
31324189
)
Facial attractiveness (female raters) (
30946739
)
Heel bone mineral density (
30598549
)
Platelet count (
32888494
)
Platelet distribution width (
32888494
)
Plateletcrit (
32888494
)
Prostate cancer (
23535732
)
Taxane-induced peripheral neuropathy in breast cancer (
29278617
)
Type 2 diabetes (
23300278
)
Waist circumference adjusted for body mass index (
28552196
)
Interacting Genes
96 interacting genes:
ADCY8
AKAP6
AKT1
AKT3
AMOTL2
APC
AXIN1
BCL2
BEST1
BMPR1B
BRAF
C3orf36
CAD
CAMK1
CARD11
CAV1
CCNG1
CCNG2
CDC42BPB
CDK2
CDK6
CDKN2C
CEBPA
CHEK2
CLPP
CSNK2B
CXCR2
DELEC1
DVL3
EEF2
EIF4EBP1
ETF1
FCAR
GABRB3
GAD1
GOLGA2
HTT
IGBP1
ISYNA1
JAK2
KISS1R
L3MBTL3
MAPK1
MAPK3
MAPT
MID1
MRPS26
MYC
MYH9
NME2
NOSIP
NXN
PACS1
PAK1
PIM1
PPP1CA
PPP2R1A
PPP2R1B
PPP2R2A
PPP2R3B
PPP2R5B
PPP2R5C
PPP2R5E
PRKAA1
PRKCD
PTEN
PTN
PXN
PYGM
RACGAP1
RBL2
RELA
RHO
RHOB
RORC
RPS6KB1
RRAS
SET
SGK1
SGO1
SGO2
STAT5A
STAT5B
STRN
TIAM1
TLX1
TP53
TRIM28
TRIM35
TRIP13
TSC2
UBAP2
VAC14
VDR
XRN1
YPEL3
1 interacting genes:
PPP2CA
Entrez ID
5515
64359
HPRD ID
08912
14858
Ensembl ID
ENSG00000113575
ENSG00000167693
Uniprot IDs
B3KUN1
P67775
Q6DKJ4
PDB IDs
2IAE
2IE3
2IE4
2NPP
2NYL
2NYM
3C5W
3DW8
3FGA
3K7V
3K7W
3P71
4I5L
4I5N
4IYP
4LAC
5W0W
6NTS
Enriched GO Terms of Interacting Partners
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