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POLA1 and IL1RAPL1
Data Source:
HPRD
(in vitro, two hybrid)
POLA1
IL1RAPL1
Description
DNA polymerase alpha 1, catalytic subunit
interleukin 1 receptor accessory protein like 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nuclear Envelope
Nucleoplasm
Alpha DNA Polymerase:primase Complex
Nucleolus
Cytosol
Nuclear Matrix
Cytoplasm
Plasma Membrane
Cell Surface
Integral Component Of Membrane
Axon
Dendrite
Postsynaptic Membrane
Glutamatergic Synapse
Molecular Function
Nucleotide Binding
DNA Binding
Chromatin Binding
DNA Replication Origin Binding
Single-stranded DNA Binding
DNA-directed DNA Polymerase Activity
Protein Binding
Purine Nucleotide Binding
Pyrimidine Nucleotide Binding
Protein Kinase Binding
Metal Ion Binding
4 Iron, 4 Sulfur Cluster Binding
Signaling Receptor Binding
Protein Binding
Interleukin-1 Binding
NAD(P)+ Nucleosidase Activity
NAD+ Nucleotidase, Cyclic ADP-ribose Generating
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
DNA Synthesis Involved In DNA Repair
DNA Replication
DNA Replication, Synthesis Of RNA Primer
DNA Replication Initiation
DNA Strand Elongation Involved In DNA Replication
Leading Strand Elongation
Lagging Strand Elongation
DNA Repair
Nucleotide-excision Repair
Double-strand Break Repair Via Nonhomologous End Joining
Viral Process
Telomere Maintenance Via Semi-conservative Replication
Regulation Of Type I Interferon Production
Mitotic DNA Replication Initiation
DNA Synthesis Involved In UV-damage Excision Repair
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Signal Transduction
Regulation Of Neuron Projection Development
Neuron Differentiation
Negative Regulation Of Exocytosis
Positive Regulation Of Dendrite Morphogenesis
Positive Regulation Of Synapse Assembly
Cellular Response To Cytokine Stimulus
Presynaptic Membrane Assembly
Regulation Of Postsynapse Organization
Trans-synaptic Signaling By Trans-synaptic Complex
Regulation Of Presynapse Assembly
Pathways
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Polymerase switching on the C-strand of the telomere
Telomere C-strand synthesis initiation
DNA replication initiation
Activation of the pre-replicative complex
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
G1/S-Specific Transcription
Receptor-type tyrosine-protein phosphatases
Interleukin-38 signaling
Drugs
Cladribine
Clofarabine
Fludarabine
Nelarabine
Diseases
Non-syndromic X-linked mental retardation
GWAS
Mean platelet volume (
32888494
)
Platelet count (
32888494
)
Cardiovascular risk factors (age interaction) (
20838585
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Vitiligo (
27723757
)
Interacting Genes
20 interacting genes:
CCNA2
CCNB1
CDC45
CDK1
CDK2
CDK2AP1
GINS4
HELB
PARP1
POLA2
POLE
PRIM2
RAD51
RB1
RBMS1
SERPINA3
SMC1A
SUMO2
TP53
XRCC5
2 interacting genes:
ARHGAP22
NCS1
Entrez ID
5422
11141
HPRD ID
02416
02193
Ensembl ID
ENSG00000101868
ENSG00000169306
Uniprot IDs
A6NMQ1
P09884
Q9NZN1
X5DNQ7
PDB IDs
1K0P
1K18
1N5G
4Q5V
4QCL
4Y97
5EXR
5IUD
6AS7
1T3G
4M92
5WY8
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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