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NANS and BCL10
Data Source:
BioGRID
(two hybrid)
NANS
BCL10
Description
N-acetylneuraminate synthase
BCL10 immune signaling adaptor
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Extracellular Exosome
Immunological Synapse
Polkadots
Nucleus
Cytoplasm
Lysosome
Cytosol
Cytoplasmic Microtubule
CBM Complex
Protein-containing Complex
Membrane Raft
Perinuclear Region Of Cytoplasm
Molecular Function
N-acylneuraminate Cytidylyltransferase Activity
N-acylneuraminate-9-phosphate Synthase Activity
N-acetylneuraminate Synthase Activity
Protease Binding
Transcription Coactivator Activity
Protein Binding
Protein C-terminus Binding
Transcription Factor Binding
Kinase Activator Activity
Enzyme Binding
Kinase Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Kinase B Binding
Protein Self-association
Protein-containing Complex Binding
CARD Domain Binding
NF-kappaB Binding
Biological Process
CMP-N-acetylneuraminate Biosynthetic Process
Carbohydrate Biosynthetic Process
Glycosylation
B Cell Apoptotic Process
Neural Tube Closure
Stimulatory C-type Lectin Receptor Signaling Pathway
Toll-like Receptor Signaling Pathway
Adaptive Immune Response
Negative Regulation Of Mature B Cell Apoptotic Process
Cellular Defense Response
I-kappaB Kinase/NF-kappaB Signaling
Cell Death
Response To Fungus
Immunoglobulin Mediated Immune Response
Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Lipopolysaccharide-mediated Signaling Pathway
Response To Food
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Lymphotoxin A Production
Positive Regulation Of Mast Cell Cytokine Production
Positive Regulation Of Kinase Activity
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
T Cell Receptor Signaling Pathway
Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Positive Regulation Of NF-kappaB Transcription Factor Activity
T Cell Apoptotic Process
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Sialic acid metabolism
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
Downstream TCR signaling
FCERI mediated NF-kB activation
FCERI mediated NF-kB activation
CLEC7A (Dectin-1) signaling
E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS
Alopecia areata (
25608926
)
Apolipoprotein A1 levels (
32203549
)
HDL cholesterol levels (
32203549
)
Metabolite levels (
23823483
)
Multiple sclerosis (
24076602
)
Interacting Genes
19 interacting genes:
APC
AURKA
BCL10
BUB1
CDH1
CTNNA1
EGFR
FBXO7
FBXW7
FLCN
MCC
MLH3
MSH6
ODC1
PDGFRL
PTPRJ
SRC
STK11
TLR2
46 interacting genes:
AKT1
ANP32B
ATM
BAAT
BIRC3
CARD10
CARD11
CARD14
CARD19
CARD9
CASP9
CCDC180
CDC14B
CDK9
CHUK
COG6
FBP1
HEMGN
IKBKG
IL15RA
IRAK1
MALT1
MAP3K7
MIB2
NANS
NLRC4
OTULIN
PELI2
PRRG4
RASA1
RIPK2
RNF181
SLC20A1
SLC9A3R1
SOCS3
SRSF1
TGFB1
TLR4
TNFRSF10A
TNFRSF1A
TRADD
TRAF2
TRMO
UBE2N
UBE2V2
USHBP1
Entrez ID
54187
8915
HPRD ID
07285
04625
Ensembl ID
ENSG00000095380
ENSG00000142867
Uniprot IDs
Q9NR45
A0A087WWW9
A2TDT2
O95999
PDB IDs
1WVO
2MB9
6BZE
6GK2
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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